The role of chemokines, cytokines and adhesion molecules in stem cell trafficking and homing

Y. Cui, P. Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.

Original languageEnglish
Pages (from-to)3271-3279
Number of pages9
JournalCurrent Pharmaceutical Design
Volume17
Issue number30
Publication statusPublished - 2011

Keywords

  • Cardiovascular disease
  • Homing
  • Ischemia
  • Repair
  • Signalling
  • Stem cells

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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