The role of choline positron emission tomography/computed tomography in the management of patients with prostate-specific antigen progression after radical treatment of prostate cancer

Maria Picchio, Alberto Briganti, Stefano Fanti, Axel Heidenreich, Bernd J. Krause, Cristina Messa, Francesco Montorsi, Sven N. Reske, George N. Thalmann

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Choline positron emission tomography (PET)/computed tomography (CT) is a currently used diagnostic tool in restaging prostate cancer (PCa) patients with increasing prostate-specific antigen (PSA) after either radical prostatectomy (RP) or external-beam radiation therapy (EBRT). However, no final recommendations have been made on the use of this modality for patient management. Objective: To critically analyse the current evidence for the use of choline PET/CT scanning in the management of patients with a progressive increase in PSA after radical treatment for PCa, evaluating its diagnostic accuracy in the detection of recurrences, the clinical predictors of positive PET/CT examinations, and the modalities' role as a guide for tailored therapeutic strategies. Evidence acquisition: Data on recently published (2003-2010) original articles, review articles, and editorials concerning the role of choline PET/CT in this scenario were analysed. Evidence synthesis: The diagnostic accuracy of choline PET in detecting sites of PCa relapse has been investigated by several authors, and the overall reported sensitivity ranges between 38% and 98%. It has been demonstrated that choline PET technology's positive detection rate improves with increasing PSA values. The routine use of choline PET/CT cannot be recommended for PSA values

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalEuropean Urology
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Choline
  • Molecular imaging
  • PET
  • PET/CT
  • Prostate cancer
  • Recurrence

ASJC Scopus subject areas

  • Urology

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