The role of circulating cytokines in colorectal carcinoma

T. Siragusa, A. R. Miller, C. Belluco, D. Nitti, M. Lise, J. M. Jessup

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Host-tumor interactions are primarily controlled by paracrine interactions between adjacent normal host cells and malignant cells. Recent evidence from experimental and clinical neoplasms indicates that neoplasms, or their products, produce levels of circulating pro- and anti-inflammatory cytokines that modulate these local paracrine interactions in such a way that promotes tumor growth. This brief review focuses on several cytokines (interleukin-6, interleukin-10, transforming growth factor-beta, and vascular endothelial growth factor) that have systemic effects in experimental models and are associated with prognosis in patients with colorectal carcinoma. The primary focus of this review is on colorectal carcinoma, but implications for other malignancies are also considered. Colorectal and similar carcinomas may exert systemic control over neoplastic progression by modulating circulating levels of cytokines that then influence the growth of distant metastasis by affecting local paracrine interactions.

Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalInternational Journal of Clinical Oncology
Volume5
Issue number4
Publication statusPublished - 2000

Fingerprint

Colorectal Neoplasms
Cytokines
Experimental Neoplasms
Neoplasms
Growth
Transforming Growth Factor beta
Interleukin-10
Vascular Endothelial Growth Factor A
Interleukin-6
Anti-Inflammatory Agents
Theoretical Models
Neoplasm Metastasis

Keywords

  • Colorectal carcinoma
  • Cytokines
  • IL-10
  • IL-6
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Siragusa, T., Miller, A. R., Belluco, C., Nitti, D., Lise, M., & Jessup, J. M. (2000). The role of circulating cytokines in colorectal carcinoma. International Journal of Clinical Oncology, 5(4), 217-228.

The role of circulating cytokines in colorectal carcinoma. / Siragusa, T.; Miller, A. R.; Belluco, C.; Nitti, D.; Lise, M.; Jessup, J. M.

In: International Journal of Clinical Oncology, Vol. 5, No. 4, 2000, p. 217-228.

Research output: Contribution to journalArticle

Siragusa, T, Miller, AR, Belluco, C, Nitti, D, Lise, M & Jessup, JM 2000, 'The role of circulating cytokines in colorectal carcinoma', International Journal of Clinical Oncology, vol. 5, no. 4, pp. 217-228.
Siragusa, T. ; Miller, A. R. ; Belluco, C. ; Nitti, D. ; Lise, M. ; Jessup, J. M. / The role of circulating cytokines in colorectal carcinoma. In: International Journal of Clinical Oncology. 2000 ; Vol. 5, No. 4. pp. 217-228.
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