The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults

M. E. Zanolin; C. Pattaro; A. Corsico; M. Bugiani; L. Carrozzi; L. Casali; R. Dallari; M. Ferrari; A. Marinoni; E. Migliore; M. Olivieri; P. Pirina; G. Verlato; S. Villani; R. de Marco; O. Buriani; R. Cavallini; C. Saletti; M. Cellini; M. Faustini; A. de Togni; A. Carolei; C. Montomoli; M. Comelli; M. Ponzio; M. Grassi; C. Rezzani; I. Cerveri; M. C. Zoia; S. Colato; G. Moscato; L. Perfetti; G. Viegi; F. Pistelli; F. di Pede; P. L. Paggiaro; A. Santolicandro; P. Giovannetti; F. Ginesu; S. Ostera; G. P. Pinna; A. Farre; S. Imparato; E. Turrini; M. Foglia; G. Giammanco; S. Pignato; A. Rotondo; A. Cuspilici; P. Piccioni; A. Carosso; W. Arossa; E. Caria; G. Castiglioni; C. Romano; D. Fabbro; G. Ciccone; C. Magnani; P. Dalmasso; R. Bono; G. Gigli; A. Giraudo; M. C. Brussino; C. Bucca; G. Rolla; P. Struzzo; U. Orefice; M. Schneider; F. Chittaro; D. Peresson; G. Verlato; S. Accordini; M. E. Zanolin; F. Locatelli; L. Cazzoletti; S. Sartori; A. Poli; N. Dorigo; S. Cantarelli; D. Ciresola; V. Lo Cascio; C. Biasin; P. Lauriola; G. Danielli; D. Sesti; E. Ghigli; P. Natale; M. Grosa; A. Tacconi; P. Frontero; A. Salomoni

doi:10.1046/j.1398-9995.2003.00391.x

The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults

M. E. Zanolin, C. Pattaro, A. Corsico, M. Bugiani, L. Carrozzi, L. Casali, R. Dallari, M. Ferrari, A. Marinoni, E. Migliore, M. Olivieri, P. Pirina, G. Verlato, S. Villani, R. de Marco, O. Buriani, R. Cavallini, C. Saletti, M. Cellini, M. FaustiniA. de Togni, A. Carolei, C. Montomoli, M. Comelli, M. Ponzio, M. Grassi, C. Rezzani, I. Cerveri, M. C. Zoia, S. Colato, G. Moscato, L. Perfetti, G. Viegi, F. Pistelli, F. di Pede, P. L. Paggiaro, A. Santolicandro, P. Giovannetti, F. Ginesu, S. Ostera, G. P. Pinna, A. Farre, S. Imparato, E. Turrini, M. Foglia, G. Giammanco, S. Pignato, A. Rotondo, A. Cuspilici, P. Piccioni, A. Carosso, W. Arossa, E. Caria, G. Castiglioni, C. Romano, D. Fabbro, G. Ciccone, C. Magnani, P. Dalmasso, R. Bono, G. Gigli, A. Giraudo, M. C. Brussino, C. Bucca, G. Rolla, P. Struzzo, U. Orefice, M. Schneider, F. Chittaro, D. Peresson, G. Verlato, S. Accordini, M. E. Zanolin, F. Locatelli, L. Cazzoletti, S. Sartori, A. Poli, N. Dorigo, S. Cantarelli, D. Ciresola, V. Lo Cascio, C. Biasin, P. Lauriola, G. Danielli, D. Sesti, E. Ghigli, P. Natale, M. Grosa, A. Tacconi, P. Frontero, A. Salomoni

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north-south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P <0.05], at a decreasing distance from the sea (OR: 0.90-0.93 for 30 km distance, P <0.05), at higher annual mean temperatures (OR: 1.11-1.14, P <0.05) and at smaller annual temperature ranges (OR: 0.94-0.95, P <0.05). Of the geo-climatic variables considered, temperature range had the greatest influence on most asthma-like symptoms. No association was found between geo-climatic variables and allergic rhinitis or chronic cough and phlegm. Conclusions: Asthma prevalence seems to be significantly affected by climate as asthma-like symptoms were more common in central-southern Italy, with a Mediterranean climate, than in areas with a continental climate (northern Italy).

Original language	English
Pages (from-to)	306-314
Number of pages	9
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1046/j.1398-9995.2003.00391.x
Publication status	Published - Mar 2004

Keywords

Asthma epidemiology
Asthma prevalence allergy
Climate
Geographic pattern
Latitude

ASJC Scopus subject areas

Immunology

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10.1046/j.1398-9995.2003.00391.x

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Zanolin, M. E., Pattaro, C., Corsico, A., Bugiani, M., Carrozzi, L., Casali, L., Dallari, R., Ferrari, M., Marinoni, A., Migliore, E., Olivieri, M., Pirina, P., Verlato, G., Villani, S., de Marco, R., Buriani, O., Cavallini, R., Saletti, C., Cellini, M., ... Salomoni, A. (2004). The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults. Allergy: European Journal of Allergy and Clinical Immunology, 59(3), 306-314. https://doi.org/10.1046/j.1398-9995.2003.00391.x

The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms : Results from the Italian study of asthma in young adults. / Zanolin, M. E.; Pattaro, C.; Corsico, A.; Bugiani, M.; Carrozzi, L.; Casali, L.; Dallari, R.; Ferrari, M.; Marinoni, A.; Migliore, E.; Olivieri, M.; Pirina, P.; Verlato, G.; Villani, S.; de Marco, R.; Buriani, O.; Cavallini, R.; Saletti, C.; Cellini, M.; Faustini, M.; de Togni, A.; Carolei, A.; Montomoli, C.; Comelli, M.; Ponzio, M.; Grassi, M.; Rezzani, C.; Cerveri, I.; Zoia, M. C.; Colato, S.; Moscato, G.; Perfetti, L.; Viegi, G.; Pistelli, F.; di Pede, F.; Paggiaro, P. L.; Santolicandro, A.; Giovannetti, P.; Ginesu, F.; Ostera, S.; Pinna, G. P.; Farre, A.; Imparato, S.; Turrini, E.; Foglia, M.; Giammanco, G.; Pignato, S.; Rotondo, A.; Cuspilici, A.; Piccioni, P.; Carosso, A.; Arossa, W.; Caria, E.; Castiglioni, G.; Romano, C.; Fabbro, D.; Ciccone, G.; Magnani, C.; Dalmasso, P.; Bono, R.; Gigli, G.; Giraudo, A.; Brussino, M. C.; Bucca, C.; Rolla, G.; Struzzo, P.; Orefice, U.; Schneider, M.; Chittaro, F.; Peresson, D.; Verlato, G.; Accordini, S.; Zanolin, M. E.; Locatelli, F.; Cazzoletti, L.; Sartori, S.; Poli, A.; Dorigo, N.; Cantarelli, S.; Ciresola, D.; Lo Cascio, V.; Biasin, C.; Lauriola, P.; Danielli, G.; Sesti, D.; Ghigli, E.; Natale, P.; Grosa, M.; Tacconi, A.; Frontero, P.; Salomoni, A.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 59, No. 3, 03.2004, p. 306-314.

Research output: Contribution to journal › Article › peer-review

Zanolin, ME, Pattaro, C, Corsico, A, Bugiani, M, Carrozzi, L, Casali, L, Dallari, R, Ferrari, M, Marinoni, A, Migliore, E, Olivieri, M, Pirina, P, Verlato, G, Villani, S, de Marco, R, Buriani, O, Cavallini, R, Saletti, C, Cellini, M, Faustini, M, de Togni, A, Carolei, A, Montomoli, C, Comelli, M, Ponzio, M, Grassi, M, Rezzani, C, Cerveri, I, Zoia, MC, Colato, S, Moscato, G, Perfetti, L, Viegi, G, Pistelli, F, di Pede, F, Paggiaro, PL, Santolicandro, A, Giovannetti, P, Ginesu, F, Ostera, S, Pinna, GP, Farre, A, Imparato, S, Turrini, E, Foglia, M, Giammanco, G, Pignato, S, Rotondo, A, Cuspilici, A, Piccioni, P, Carosso, A, Arossa, W, Caria, E, Castiglioni, G, Romano, C, Fabbro, D, Ciccone, G, Magnani, C, Dalmasso, P, Bono, R, Gigli, G, Giraudo, A, Brussino, MC, Bucca, C, Rolla, G, Struzzo, P, Orefice, U, Schneider, M, Chittaro, F, Peresson, D, Verlato, G, Accordini, S, Zanolin, ME, Locatelli, F, Cazzoletti, L, Sartori, S, Poli, A, Dorigo, N, Cantarelli, S, Ciresola, D, Lo Cascio, V, Biasin, C, Lauriola, P, Danielli, G, Sesti, D, Ghigli, E, Natale, P, Grosa, M, Tacconi, A, Frontero, P & Salomoni, A 2004, 'The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults', Allergy: European Journal of Allergy and Clinical Immunology, vol. 59, no. 3, pp. 306-314. https://doi.org/10.1046/j.1398-9995.2003.00391.x

Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L et al. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults. Allergy: European Journal of Allergy and Clinical Immunology. 2004 Mar;59(3):306-314. https://doi.org/10.1046/j.1398-9995.2003.00391.x

Zanolin, M. E. ; Pattaro, C. ; Corsico, A. ; Bugiani, M. ; Carrozzi, L. ; Casali, L. ; Dallari, R. ; Ferrari, M. ; Marinoni, A. ; Migliore, E. ; Olivieri, M. ; Pirina, P. ; Verlato, G. ; Villani, S. ; de Marco, R. ; Buriani, O. ; Cavallini, R. ; Saletti, C. ; Cellini, M. ; Faustini, M. ; de Togni, A. ; Carolei, A. ; Montomoli, C. ; Comelli, M. ; Ponzio, M. ; Grassi, M. ; Rezzani, C. ; Cerveri, I. ; Zoia, M. C. ; Colato, S. ; Moscato, G. ; Perfetti, L. ; Viegi, G. ; Pistelli, F. ; di Pede, F. ; Paggiaro, P. L. ; Santolicandro, A. ; Giovannetti, P. ; Ginesu, F. ; Ostera, S. ; Pinna, G. P. ; Farre, A. ; Imparato, S. ; Turrini, E. ; Foglia, M. ; Giammanco, G. ; Pignato, S. ; Rotondo, A. ; Cuspilici, A. ; Piccioni, P. ; Carosso, A. ; Arossa, W. ; Caria, E. ; Castiglioni, G. ; Romano, C. ; Fabbro, D. ; Ciccone, G. ; Magnani, C. ; Dalmasso, P. ; Bono, R. ; Gigli, G. ; Giraudo, A. ; Brussino, M. C. ; Bucca, C. ; Rolla, G. ; Struzzo, P. ; Orefice, U. ; Schneider, M. ; Chittaro, F. ; Peresson, D. ; Verlato, G. ; Accordini, S. ; Zanolin, M. E. ; Locatelli, F. ; Cazzoletti, L. ; Sartori, S. ; Poli, A. ; Dorigo, N. ; Cantarelli, S. ; Ciresola, D. ; Lo Cascio, V. ; Biasin, C. ; Lauriola, P. ; Danielli, G. ; Sesti, D. ; Ghigli, E. ; Natale, P. ; Grosa, M. ; Tacconi, A. ; Frontero, P. ; Salomoni, A. / The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms : Results from the Italian study of asthma in young adults. In: Allergy: European Journal of Allergy and Clinical Immunology. 2004 ; Vol. 59, No. 3. pp. 306-314.

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title = "The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults",

abstract = "Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north-south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P <0.05], at a decreasing distance from the sea (OR: 0.90-0.93 for 30 km distance, P <0.05), at higher annual mean temperatures (OR: 1.11-1.14, P <0.05) and at smaller annual temperature ranges (OR: 0.94-0.95, P <0.05). Of the geo-climatic variables considered, temperature range had the greatest influence on most asthma-like symptoms. No association was found between geo-climatic variables and allergic rhinitis or chronic cough and phlegm. Conclusions: Asthma prevalence seems to be significantly affected by climate as asthma-like symptoms were more common in central-southern Italy, with a Mediterranean climate, than in areas with a continental climate (northern Italy).",

keywords = "Asthma epidemiology, Asthma prevalence allergy, Climate, Geographic pattern, Latitude",

author = "Zanolin, {M. E.} and C. Pattaro and A. Corsico and M. Bugiani and L. Carrozzi and L. Casali and R. Dallari and M. Ferrari and A. Marinoni and E. Migliore and M. Olivieri and P. Pirina and G. Verlato and S. Villani and {de Marco}, R. and O. Buriani and R. Cavallini and C. Saletti and M. Cellini and M. Faustini and {de Togni}, A. and A. Carolei and C. Montomoli and M. Comelli and M. Ponzio and M. Grassi and C. Rezzani and I. Cerveri and Zoia, {M. C.} and S. Colato and G. Moscato and L. Perfetti and G. Viegi and F. Pistelli and {di Pede}, F. and Paggiaro, {P. L.} and A. Santolicandro and P. Giovannetti and F. Ginesu and S. Ostera and Pinna, {G. P.} and A. Farre and S. Imparato and E. Turrini and M. Foglia and G. Giammanco and S. Pignato and A. Rotondo and A. Cuspilici and P. Piccioni and A. Carosso and W. Arossa and E. Caria and G. Castiglioni and C. Romano and D. Fabbro and G. Ciccone and C. Magnani and P. Dalmasso and R. Bono and G. Gigli and A. Giraudo and Brussino, {M. C.} and C. Bucca and G. Rolla and P. Struzzo and U. Orefice and M. Schneider and F. Chittaro and D. Peresson and G. Verlato and S. Accordini and Zanolin, {M. E.} and F. Locatelli and L. Cazzoletti and S. Sartori and A. Poli and N. Dorigo and S. Cantarelli and D. Ciresola and {Lo Cascio}, V. and C. Biasin and P. Lauriola and G. Danielli and D. Sesti and E. Ghigli and P. Natale and M. Grosa and A. Tacconi and P. Frontero and A. Salomoni",

year = "2004",

month = mar,

doi = "10.1046/j.1398-9995.2003.00391.x",

language = "English",

volume = "59",

pages = "306--314",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms

T2 - Results from the Italian study of asthma in young adults

AU - Zanolin, M. E.

AU - Pattaro, C.

AU - Corsico, A.

AU - Bugiani, M.

AU - Carrozzi, L.

AU - Casali, L.

AU - Dallari, R.

AU - Ferrari, M.

AU - Marinoni, A.

AU - Migliore, E.

AU - Olivieri, M.

AU - Pirina, P.

AU - Verlato, G.

AU - Villani, S.

AU - de Marco, R.

AU - Buriani, O.

AU - Cavallini, R.

AU - Saletti, C.

AU - Cellini, M.

AU - Faustini, M.

AU - de Togni, A.

AU - Carolei, A.

AU - Montomoli, C.

AU - Comelli, M.

AU - Ponzio, M.

AU - Grassi, M.

AU - Rezzani, C.

AU - Cerveri, I.

AU - Zoia, M. C.

AU - Colato, S.

AU - Moscato, G.

AU - Perfetti, L.

AU - Viegi, G.

AU - Pistelli, F.

AU - di Pede, F.

AU - Paggiaro, P. L.

AU - Santolicandro, A.

AU - Giovannetti, P.

AU - Ginesu, F.

AU - Ostera, S.

AU - Pinna, G. P.

AU - Farre, A.

AU - Imparato, S.

AU - Turrini, E.

AU - Foglia, M.

AU - Giammanco, G.

AU - Pignato, S.

AU - Rotondo, A.

AU - Cuspilici, A.

AU - Piccioni, P.

AU - Carosso, A.

AU - Arossa, W.

AU - Caria, E.

AU - Castiglioni, G.

AU - Romano, C.

AU - Fabbro, D.

AU - Ciccone, G.

AU - Magnani, C.

AU - Dalmasso, P.

AU - Bono, R.

AU - Gigli, G.

AU - Giraudo, A.

AU - Brussino, M. C.

AU - Bucca, C.

AU - Rolla, G.

AU - Struzzo, P.

AU - Orefice, U.

AU - Schneider, M.

AU - Chittaro, F.

AU - Peresson, D.

AU - Verlato, G.

AU - Accordini, S.

AU - Zanolin, M. E.

AU - Locatelli, F.

AU - Cazzoletti, L.

AU - Sartori, S.

AU - Poli, A.

AU - Dorigo, N.

AU - Cantarelli, S.

AU - Ciresola, D.

AU - Lo Cascio, V.

AU - Biasin, C.

AU - Lauriola, P.

AU - Danielli, G.

AU - Sesti, D.

AU - Ghigli, E.

AU - Natale, P.

AU - Grosa, M.

AU - Tacconi, A.

AU - Frontero, P.

AU - Salomoni, A.

PY - 2004/3

Y1 - 2004/3

N2 - Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north-south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P <0.05], at a decreasing distance from the sea (OR: 0.90-0.93 for 30 km distance, P <0.05), at higher annual mean temperatures (OR: 1.11-1.14, P <0.05) and at smaller annual temperature ranges (OR: 0.94-0.95, P <0.05). Of the geo-climatic variables considered, temperature range had the greatest influence on most asthma-like symptoms. No association was found between geo-climatic variables and allergic rhinitis or chronic cough and phlegm. Conclusions: Asthma prevalence seems to be significantly affected by climate as asthma-like symptoms were more common in central-southern Italy, with a Mediterranean climate, than in areas with a continental climate (northern Italy).

AB - Background: Variations in the prevalence of respiratory symptoms according to geo-climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo-climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate potential trends. Results: The prevalence of all symptoms was significantly heterogeneous throughout the peninsula. Only asthma-like symptoms showed a north-south trend: the prevalence increased at a decreasing latitude [odds ratio (OR) varies from 0.92 to 0.96, P <0.05], at a decreasing distance from the sea (OR: 0.90-0.93 for 30 km distance, P <0.05), at higher annual mean temperatures (OR: 1.11-1.14, P <0.05) and at smaller annual temperature ranges (OR: 0.94-0.95, P <0.05). Of the geo-climatic variables considered, temperature range had the greatest influence on most asthma-like symptoms. No association was found between geo-climatic variables and allergic rhinitis or chronic cough and phlegm. Conclusions: Asthma prevalence seems to be significantly affected by climate as asthma-like symptoms were more common in central-southern Italy, with a Mediterranean climate, than in areas with a continental climate (northern Italy).

KW - Asthma epidemiology

KW - Asthma prevalence allergy

KW - Climate

KW - Geographic pattern

KW - Latitude

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U2 - 10.1046/j.1398-9995.2003.00391.x

DO - 10.1046/j.1398-9995.2003.00391.x

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EP - 314

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 3

ER -

The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: Results from the Italian study of asthma in young adults

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