The role of cognitive rehabilitation in limbic encephalitis: A case report

Francesco Corallo, Viviana Lo Buono, Marcella Di Cara, Simona De Salvo, Caterina Formica, Rosa Morabito, Daniela Floridia, Concetta Pastura, Carmela Rifici, Giangaetano D'Aleo, Edoardo Sessa, Placido Bramanti, Silvia Marino

Research output: Contribution to journalArticle


RATIONALE: Limbic encephalitis is a parenchymal inflammation caused by viral, bacterial, or other microbial and postinfectious agents, which is usually expressed by multifocal neurological signs and cognitive impairment.

PATIENT CONCERNS: A 50-year-old female was admitted in postacute phase, at our rehabilitative Center, to undertake neuro-motor treatment for a period of 4 months.

DIAGNOSES: The patient was affected by limbic encephalitis. Clinical presentation revealed attention, memory and executive dysfunctions, as well as behavioral changes, emotional dysregulation and reduction of self-awareness.

INTERVENTIONS: The patients received an intensive cognitive and motor rehabilitation training.

OUTCOMES: Neuropsychological assessment and magnetic resonance imaging were performed before and after rehabilitative training to evaluate the cognitive and cerebral changes induced by treatment. The patient showed an improvement in cognitive performances and behavioral aspects.

LESSONS: The reducing cognitive deficits, especially memory deficits, could improve quality of life by using available cognitive resources.

Original languageEnglish
Pages (from-to)e13223
Issue number48
Publication statusPublished - Nov 2018


  • Brain/diagnostic imaging
  • Cognitive Dysfunction/diagnostic imaging
  • Female
  • Humans
  • Limbic Encephalitis/diagnostic imaging
  • Middle Aged

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