The role of current and new discriminating markers in the immunodiagnosis of Hodgkin's disease and other phenotypically related lymphomas.

A. Carbone, A. Gloghini

Research output: Contribution to journalArticlepeer-review

Abstract

Recent data have shown that CD40 antigen and its ligand (CD40L), and the CD26 molecule are differentially expressed among Hodgkin's disease (HD) (CD40+, CD26, CD40L), peripheral T-cell (PTCL) (CD40L+/-, CD40, CD26) and CD30 positive anaplastic large cell (ALC) (CD26+, CD40L) lymphomas. Since CD40 molecule is consistently detected on Reed-Sternberg (RS) cells and their morphologic variants with a distinctive staining pattern. CD40 expression provides a new potential tool for the identification of RS cells of HD in fixed and paraffin-embedded material. Furthermore, the combined application of anti-CD40 and anti-CD26 MoAbs may discriminate HD from morphologically and immunophenotypically related ALC lymphomas. In fact a CD26+/CD40 profile is restricted to CD30 positive ALC lymphomas. Finally, the combined application of anti-CD40 and anti-CD40L MoAbs provides additional significant features in differentiating HD from PTCL due to the constant expression of CD40+/CD40L phenotype in HD and its absence in PTCL, which in turn express CD40/CD40L+/- phenotype.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalPathologica
Volume88
Issue number3
Publication statusPublished - Jun 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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