The role of cysteine and homocysteine in venous and arterial thrombotic disease

Rossella Marcucci, Tamara Brunelli, Betti Giusti, Sandra Fedi, Guglielmina Pepe, Daniela Poli, Domenico Prisco, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume116
Issue number1
DOIs
Publication statusPublished - Jul 2001

Keywords

  • Cysteine
  • Homocysteine
  • Methionine
  • Thrombophilia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Marcucci, R., Brunelli, T., Giusti, B., Fedi, S., Pepe, G., Poli, D., Prisco, D., Abbate, R., & Gensini, G. F. (2001). The role of cysteine and homocysteine in venous and arterial thrombotic disease. American Journal of Clinical Pathology, 116(1), 56-60. https://doi.org/10.1309/7A33-8EQ4-QT98-3TPX