The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea

Francesco Drago, Giulia Ciccarese, Francesco Broccolo, Massimo Ghio, Paola Contini, Hajdhica Thanasi, Aurora Parodi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction. Pityriasis rosea (PR) is an exanthematous disease related to human herpesvirus- (HHV-) 6/7 reactivation. The network of mediators involved in recruiting the infiltrating inflammatory cells has never been studied. Object. To investigate the levels of serum cytokines, growth factors, and chemokines in PR and healthy controls in order to elucidate the PR pathogenesis. Materials and Methods. Interleukin- (IL-) 1, IL-6, IL-17, interferon- (IFN-) γ, tumor necrosis factor- (TNF-) vascular endothelial growth factor (VEGF), granulocyte colony stimulating factor (G-CSF), and chemokines, CXCL8 (IL-8) and CXCL10 (IP-10), were measured simultaneously by a multiplex assay in early acute PR patients' sera and healthy controls. Subsequently, sera from PR patients were analysed at 3 different times (0, 15, and 30 days). Results and discussion. Serum levels of IL-17, IFN-γ, VEGF, and IP-10 resulted to be upregulated in PR patients compared to controls. IL-17 has a key role in host defense against pathogens stimulating the release of proinflammatory cytokines/chemokines. IFN-γ has a direct antiviral activity promoting NK cells and virus specific T cells cytotoxicity. VEGF stimulates vasculogenesis and angiogenesis. IP-10 can induce chemotaxis, apoptosis, cell growth, and angiogenesis. Conclusions. Our findings suggest that these inflammatory mediators may modulate PR pathogenesis in synergistic manner.

Original languageEnglish
Article number438963
JournalMediators of Inflammation
Volume2015
DOIs
Publication statusPublished - 2015

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Pityriasis Rosea
Chemokines
Intercellular Signaling Peptides and Proteins
Cytokines
Interleukin-17
Interferons
Vascular Endothelial Growth Factor A
Serum
Interleukin-8
Human Herpesvirus 7
Human Herpesvirus 6
Granulocyte Colony-Stimulating Factor
Chemotaxis
Interleukin-1
Natural Killer Cells
Antiviral Agents
Interleukin-6
Tumor Necrosis Factor-alpha
Apoptosis
Viruses

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea. / Drago, Francesco; Ciccarese, Giulia; Broccolo, Francesco; Ghio, Massimo; Contini, Paola; Thanasi, Hajdhica; Parodi, Aurora.

In: Mediators of Inflammation, Vol. 2015, 438963, 2015.

Research output: Contribution to journalArticle

Drago, Francesco ; Ciccarese, Giulia ; Broccolo, Francesco ; Ghio, Massimo ; Contini, Paola ; Thanasi, Hajdhica ; Parodi, Aurora. / The Role of Cytokines, Chemokines, and Growth Factors in the Pathogenesis of Pityriasis Rosea. In: Mediators of Inflammation. 2015 ; Vol. 2015.
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