Abstract
Most tumor-host interactions occur through the cytokines released by tumor cells and/or tumor-infiltrating leukocytes. Local exogenous administration of cytokines (especially by gene transfer) may result in tumor inhibition. However, cytokine gene transfer as an approach to curing cancer is not without many biases, which are discussed here. The methodology focuses on the detection of cytokines in situations in which few cells are available or ex vivo tissue must be examined, as occurs in studies of tumor-host interactions and when such interactions are modulated by immunological interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 34-42 |
| Number of pages | 9 |
| Journal | ImmunoMethods |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 1993 |
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ASJC Scopus subject areas
- Immunology
Cite this
The Role of Cytokines in Antitumor Immune Response : From Detection to Gene Therapy. / Colombo, Mario P.; Carè, Alessandra.
In: ImmunoMethods, Vol. 3, No. 1, 08.1993, p. 34-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Role of Cytokines in Antitumor Immune Response
T2 - From Detection to Gene Therapy
AU - Colombo, Mario P.
AU - Carè, Alessandra
PY - 1993/8
Y1 - 1993/8
N2 - Most tumor-host interactions occur through the cytokines released by tumor cells and/or tumor-infiltrating leukocytes. Local exogenous administration of cytokines (especially by gene transfer) may result in tumor inhibition. However, cytokine gene transfer as an approach to curing cancer is not without many biases, which are discussed here. The methodology focuses on the detection of cytokines in situations in which few cells are available or ex vivo tissue must be examined, as occurs in studies of tumor-host interactions and when such interactions are modulated by immunological interventions.
AB - Most tumor-host interactions occur through the cytokines released by tumor cells and/or tumor-infiltrating leukocytes. Local exogenous administration of cytokines (especially by gene transfer) may result in tumor inhibition. However, cytokine gene transfer as an approach to curing cancer is not without many biases, which are discussed here. The methodology focuses on the detection of cytokines in situations in which few cells are available or ex vivo tissue must be examined, as occurs in studies of tumor-host interactions and when such interactions are modulated by immunological interventions.
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U2 - 10.1006/immu.1993.1037
DO - 10.1006/immu.1993.1037
M3 - Article
VL - 3
SP - 34
EP - 42
JO - ImmunoMethods
JF - ImmunoMethods
SN - 1058-6687
IS - 1
ER -