The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The aim of this study was to elucidate the molecular basis for viral clearance and liver disease in the pathogenesis of hepatitis B virus (HBV) infection. Using transgenic mice that replicate HBV at high levels in the liver as recipients of HBV-specific cytotoxic T cells (CTL), we have shown that the antiviral potential of the CTL is primarily mediated by noncytolytic mechanisms that involve the intra-hepatic production of IFN-γ by these cells. We also showed that, following antigen recognition, HBV-specific CTL recruit antigen non-specific inflammatory cells that contribute to amplify the liver disease initiated by CTL. These results provided insight into immunological and virological processes that may lead to the development of new therapeutic strategies to terminate chronic HBV infection.

Original languageEnglish
JournalVaccine
Volume20
Issue numberSUPPL. 4
DOIs
Publication statusPublished - Dec 19 2002

Fingerprint

Hepatitis B virus
Virus Diseases
cytokines
T-lymphocytes
Cytokines
T-Lymphocytes
infection
liver diseases
Liver Diseases
chronic hepatitis B
antigens
Antigens
liver
Liver
Chronic Hepatitis B
Transgenic Mice
Antiviral Agents
pathogenesis
genetically modified organisms
cells

Keywords

  • CTL
  • HBV
  • IFN-γ

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection. / Guidotti, Luca G.

In: Vaccine, Vol. 20, No. SUPPL. 4, 19.12.2002.

Research output: Contribution to journalArticle

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