Abstract
T regulatory cells - in addition to clonal deletion and anergy - are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 676-683 |
| Number of pages | 8 |
| Journal | Current Opinion in Immunology |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Cite this
Roncarolo, M. G., & Levings, M. K. (2000). The role of different subsets of T regulatory cells in controlling autoimmunity. Current Opinion in Immunology, 12(6), 676-683. https://doi.org/10.1016/S0952-7915(00)00162-X