Abstract
T regulatory cells - in addition to clonal deletion and anergy - are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 676-683 |
| Number of pages | 8 |
| Journal | Current Opinion in Immunology |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
The role of different subsets of T regulatory cells in controlling autoimmunity. / Roncarolo, Maria Grazia; Levings, Megan K.
In: Current Opinion in Immunology, Vol. 12, No. 6, 2000, p. 676-683.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of different subsets of T regulatory cells in controlling autoimmunity
AU - Roncarolo, Maria Grazia
AU - Levings, Megan K.
PY - 2000
Y1 - 2000
N2 - T regulatory cells - in addition to clonal deletion and anergy - are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
AB - T regulatory cells - in addition to clonal deletion and anergy - are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033738329&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(00)00162-X
DO - 10.1016/S0952-7915(00)00162-X
M3 - Article
C2 - 11102772
AN - SCOPUS:0033738329
VL - 12
SP - 676
EP - 683
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 6
ER -