The role of different subsets of T regulatory cells in controlling autoimmunity

Maria Grazia Roncarolo, Megan K. Levings

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

T regulatory cells - in addition to clonal deletion and anergy - are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.

Original languageEnglish
Pages (from-to)676-683
Number of pages8
JournalCurrent Opinion in Immunology
Volume12
Issue number6
DOIs
Publication statusPublished - 2000

Fingerprint

Regulatory T-Lymphocytes
Autoimmunity
Clonal Anergy
Clonal Deletion
TCF Transcription Factors
Autoantigens
Autoimmune Diseases
Down-Regulation
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of different subsets of T regulatory cells in controlling autoimmunity. / Roncarolo, Maria Grazia; Levings, Megan K.

In: Current Opinion in Immunology, Vol. 12, No. 6, 2000, p. 676-683.

Research output: Contribution to journalArticle

Roncarolo, Maria Grazia ; Levings, Megan K. / The role of different subsets of T regulatory cells in controlling autoimmunity. In: Current Opinion in Immunology. 2000 ; Vol. 12, No. 6. pp. 676-683.
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