The role of dosimetry in the high activity 90Y-ibritumomab tiuxetan regimens: Two cases of abnormal biodistribution

Demetrio Aricò, Chiara Maria Grana, Anna Vanazzi, Mahila Ferrari, Andrew Mallia, Maddalena Sansovini, Giovanni Martinelli, Giovanni Paganelli, Marta Cremonesi

Research output: Contribution to journalArticle

Abstract

Radioimmunotherapy (RIT) with a commercially available brand of yttrium-90 (90Y)-ibritumomab-tiuxetan at the prescribed activity of 14.8 MBq/kg (0.4 mCi/kg) represents a complementary approach in the treatment of resistant/refractory B-cell non-Hodgkin's lymphoma. A trial based on higher activities is ongoing in our institute. In this paper, we report atypical pharmacokinetics and liver uptake in 2 patients. Before RIT, all patients underwent dosimetry with 111In-ibritumomab-tiuxetan. Imaging data were analyzed to obtain predicted absorbed doses to nontarget organs. Therapy was administered only if a 20-Gy-limit dose to normal organs (except red marrow) was guaranteed. Both patients we describe showed abnormal liver uptake, increasing for 6 days post injection. In patient 1, there was atypical biodistribution in whole-blood images at 16 hours, with a prevalent high liver uptake (45% at 20 hours). Injected activity (IA%) was above 40% at 26 hours in the liver and lower than 60% in the total body. In patient 2, early images showed regular biodistribution. Subsequent images showed progressive increase of liver uptake (above 25% of percent injected activity at 25 hours). Liver-absorbed doses of 51 and 53 Gy, respectively, would have resulted with the administration of the prescribed 56 MBq/kg. Following these dosimetric results, both patients did not receive the planned therapy. These findings support the recommendation to include dosimetry in high-dose RIT.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalCancer Biotherapy and Radiopharmaceuticals
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 1 2009

Keywords

  • Dosimetry
  • Lymphoma
  • Radioimmunotherapy
  • Transplantation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology

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