The Role of Extracellular Vesicles in Bone Metastasis

Michela Rossi, Giulia Battafarano, Matteo D'Agostini, Andrea Del Fattore

Research output: Contribution to journalReview article

Abstract

Multiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. Despite being the focus of intense investigation, the molecular and cellular mechanisms that regulate the metastasis of disseminated tumor cells still remain largely unknown. Bone metastases severely impact quality of life since they are associated with pain, fractures, and bone marrow aplasia. In this review, we will summarize the recent discoveries on the role of extracellular vesicles (EV) in the regulation of bone remodeling activity and bone metastasis occurrence. Indeed, it was shown that extracellular vesicles, including exosomes and microvesicles, released from tumor cells can modify the bone microenvironment, allowing the formation of osteolytic, osteosclerotic, and mixed mestastases. In turn, bone-derived EV can stimulate the proliferation of tumor cells. The inhibition of EV-mediated crosstalk between cancer and bone cells could represent a new therapeutic target for bone metastasis.

Original languageEnglish
Number of pages13
JournalInternational Journal of Molecular Sciences
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 10 2018

Fingerprint

metastasis
bones
Bone
Neoplasm Metastasis
Bone and Bones
tumors
Tumors
Neoplasms
Cells
Exosomes
Bone Neoplasms
Aptitude
Bone Remodeling
cancer
pain
Extracellular Vesicles
bone marrow
Bone Marrow
crosstalk
Quality of Life

Keywords

  • Animals
  • Bone Neoplasms/metabolism
  • Extracellular Vesicles/metabolism
  • Humans

Cite this

The Role of Extracellular Vesicles in Bone Metastasis. / Rossi, Michela; Battafarano, Giulia; D'Agostini, Matteo; Del Fattore, Andrea.

In: International Journal of Molecular Sciences, Vol. 19, No. 4, 10.04.2018.

Research output: Contribution to journalReview article

Rossi, Michela ; Battafarano, Giulia ; D'Agostini, Matteo ; Del Fattore, Andrea. / The Role of Extracellular Vesicles in Bone Metastasis. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 4.
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