The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: Importance of activated monocytes

G. G N Serneri, G. F. Gensini, L. Poggesi, P. A. Modesti, C. Rostagno, M. Boddi, A. M. Gori, F. Martini, A. Leri, M. Margheri, R. Abbate

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The role of thromboxane A2 (TxA2) in unstable angina has not yet been defined. TxA2 receptor antagonists may be of value in studying this role. Methods: To investigate whether TxA2 has a pathogenetic effect on the occurrence of myocardial ischemia and from what source TxA2 originates, we studied TxA2 formation by unstimulated monocytes from patients with unstable angina (n=40), stable effort angina (n=20), and controls (n=20). We also compared the effects of picotamide (1200 mg/day), a TxA2-synthase inhibitor and TxA2-receptor antagonist, with those of aspirin (325 mg/day) on myocardial ischemia and TxA2 formation by monocytes and platelets. The double-blind randomized study was performed on patients with unstable angina on continuous Holter monitoring. Results: In the presence of autologous lymphocytes, unstimulated monocytes from patients with unstable angina formed significantly (P2 than those from controls or from patients with effort angina. Although TxA2 formation by circulating monocytes and platelets was inhibited to a greater degree by aspirin than by picotamide (88±6 and 98±2%, respectively, versus 65±2 and 74±1, P2 formed by monocytes contributes to the pathogenesis of myocardial ischemia in unstable angina. TxA2 formation occurs mainly in extravascular spaces, probably within the coronary vascular wall. Picotamide appears to control myocardial ischemia effectively in patients with unstable angina.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalCoronary Artery Disease
Volume5
Issue number2
Publication statusPublished - 1994

Fingerprint

Thromboxane A2
Unstable Angina
Monocytes
Myocardial Ischemia
Prostaglandin H2 Receptors Thromboxane A2
Aspirin
Blood Platelets
Ambulatory Electrocardiography
Stable Angina
Double-Blind Method
Blood Vessels
Lymphocytes

Keywords

  • aspirin
  • coronary inflammation
  • leucocytes
  • myocardial ischemia
  • picotamide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Serneri, G. G. N., Gensini, G. F., Poggesi, L., Modesti, P. A., Rostagno, C., Boddi, M., ... Abbate, R. (1994). The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: Importance of activated monocytes. Coronary Artery Disease, 5(2), 137-145.

The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor : Importance of activated monocytes. / Serneri, G. G N; Gensini, G. F.; Poggesi, L.; Modesti, P. A.; Rostagno, C.; Boddi, M.; Gori, A. M.; Martini, F.; Leri, A.; Margheri, M.; Abbate, R.

In: Coronary Artery Disease, Vol. 5, No. 2, 1994, p. 137-145.

Research output: Contribution to journalArticle

Serneri, GGN, Gensini, GF, Poggesi, L, Modesti, PA, Rostagno, C, Boddi, M, Gori, AM, Martini, F, Leri, A, Margheri, M & Abbate, R 1994, 'The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: Importance of activated monocytes', Coronary Artery Disease, vol. 5, no. 2, pp. 137-145.
Serneri, G. G N ; Gensini, G. F. ; Poggesi, L. ; Modesti, P. A. ; Rostagno, C. ; Boddi, M. ; Gori, A. M. ; Martini, F. ; Leri, A. ; Margheri, M. ; Abbate, R. / The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor : Importance of activated monocytes. In: Coronary Artery Disease. 1994 ; Vol. 5, No. 2. pp. 137-145.
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