The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane

Domenico Ribatti, M. Presta

Research output: Contribution to journalArticle

Abstract

The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.

Original languageEnglish
Pages (from-to)439-446
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume6
Issue number3
Publication statusPublished - Jun 2002

Fingerprint

Chorioallantoic Membrane
Fibroblast Growth Factor 2
Computer aided manufacturing
Chick Embryo
Blood Vessels
Membranes
Extraembryonic Membranes
Angiogenesis Inducing Agents
Epigenomics
Intercellular Signaling Peptides and Proteins
Embryonic Structures
Gases
Assays
Cells

Keywords

  • Angiogenesis
  • Chorioallantoic membrane
  • Endothelial cell
  • Fibroblast growth factor-2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane. / Ribatti, Domenico; Presta, M.

In: Journal of Cellular and Molecular Medicine, Vol. 6, No. 3, 06.2002, p. 439-446.

Research output: Contribution to journalArticle

@article{3179857b94e245079e3b73061683c57c,
title = "The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane",
abstract = "The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.",
keywords = "Angiogenesis, Chorioallantoic membrane, Endothelial cell, Fibroblast growth factor-2",
author = "Domenico Ribatti and M. Presta",
year = "2002",
month = "6",
language = "English",
volume = "6",
pages = "439--446",
journal = "Journal of Cellular and Molecular Medicine",
issn = "1582-1838",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane

AU - Ribatti, Domenico

AU - Presta, M.

PY - 2002/6

Y1 - 2002/6

N2 - The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.

AB - The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.

KW - Angiogenesis

KW - Chorioallantoic membrane

KW - Endothelial cell

KW - Fibroblast growth factor-2

UR - http://www.scopus.com/inward/record.url?scp=0036653302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036653302&partnerID=8YFLogxK

M3 - Article

C2 - 12417062

AN - SCOPUS:0036653302

VL - 6

SP - 439

EP - 446

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

IS - 3

ER -