The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane

Domenico Ribatti, M. Presta

Research output: Contribution to journalArticlepeer-review

Abstract

The CAM is an extraembryonic membrane which serves as a gas exchange surface and its respiratory function is provided by an extensive capillary network. The development of the vascular system of the CAM is a complex, highly regulated process that depends on genetic and epigenetic factors expressed by endothelial and non-endothelial cells. In spite of the evidence that several growth factors are angiogenic in the CAM assay, poorly investigated is their role in the development of the CAM's vascular system. This article reviews our studies concerning the role of exogenous and endogenous fibroblast growth factor-2 (FGF-2) in the CAM vascularization. The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo.

Original languageEnglish
Pages (from-to)439-446
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume6
Issue number3
Publication statusPublished - Jun 2002

Keywords

  • Angiogenesis
  • Chorioallantoic membrane
  • Endothelial cell
  • Fibroblast growth factor-2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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