TY - JOUR
T1 - The role of forkhead box proteins in acute myeloid leukemia
AU - Gurnari, Carmelo
AU - Falconi, Giulia
AU - De Bellis, Eleonora
AU - Voso, Maria Teresa
AU - Fabiani, Emiliano
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different cellular functions such as differentiation, proliferation and senescence. A growing number of studies have focused on the relationship between FOX proteins and cancers, particularly hematological neoplasms such as acute myeloid leukemia (AML). FOX proteins are widely involved in AML biology, including leukemogenesis, relapse and drug sensitivity. Here we explore the role of FOX transcription factors in the major AML entities, according to “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia”, and in the context of the most recurrent gene mutations identified in this heterogeneous disease. Moreover, we report the new evidences about the role of FOX proteins in drug sensitivity, mechanisms of chemoresistance, and possible targeting for personalized therapies.
AB - Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different cellular functions such as differentiation, proliferation and senescence. A growing number of studies have focused on the relationship between FOX proteins and cancers, particularly hematological neoplasms such as acute myeloid leukemia (AML). FOX proteins are widely involved in AML biology, including leukemogenesis, relapse and drug sensitivity. Here we explore the role of FOX transcription factors in the major AML entities, according to “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia”, and in the context of the most recurrent gene mutations identified in this heterogeneous disease. Moreover, we report the new evidences about the role of FOX proteins in drug sensitivity, mechanisms of chemoresistance, and possible targeting for personalized therapies.
KW - Acute myeloid leukemia
KW - Chemoresistance
KW - Forkhead box proteins
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U2 - 10.3390/cancers11060865
DO - 10.3390/cancers11060865
M3 - Review article
AN - SCOPUS:85071174167
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 6
M1 - 865
ER -