The role of forkhead box proteins in acute myeloid leukemia

Carmelo Gurnari, Giulia Falconi, Eleonora De Bellis, Maria Teresa Voso, Emiliano Fabiani

Research output: Contribution to journalReview articlepeer-review

Abstract

Forkhead box (FOX) proteins are a group of transcriptional factors implicated in different cellular functions such as differentiation, proliferation and senescence. A growing number of studies have focused on the relationship between FOX proteins and cancers, particularly hematological neoplasms such as acute myeloid leukemia (AML). FOX proteins are widely involved in AML biology, including leukemogenesis, relapse and drug sensitivity. Here we explore the role of FOX transcription factors in the major AML entities, according to “The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia”, and in the context of the most recurrent gene mutations identified in this heterogeneous disease. Moreover, we report the new evidences about the role of FOX proteins in drug sensitivity, mechanisms of chemoresistance, and possible targeting for personalized therapies.

Original languageEnglish
Article number865
JournalCancers
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 1 2019
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Chemoresistance
  • Forkhead box proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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