The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma

G. Minniti, V. Esposito, M. Amichetti, R. Maurizi Enrici

Research output: Contribution to journalArticlepeer-review


The optimal management of craniopharyngiomas remains controversial. The first-line treatment usually consists of surgical resection. Complete tumor removal provides a high rate of long-term control; however, aggressive surgery is associated with significant incidence of complications. Radiotherapy (RT) is currently used in patients after limited surgery and achieves excellent long-term tumor control. Stereotactic radiotherapy, both in the form of radiosurgery (RS) or fractionated stereotactic radiotherapy (FSRT), has been developed as a more accurate technique of irradiation with more precise tumor localization and consequently a reduction in the volume of normal brain irradiated to high radiation doses. We provide a review of published data on outcome of conventional fractionated RT and modern radiation techniques. FSRT is a suitable treatment technique for all sizes of craniopharyngiomas, and efficacy is comparable to conventional RT. Single-fraction stereotactic radiosurgery is usually delivered to small tumors away from critical structures. Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalNeurosurgical Review
Issue number2
Publication statusPublished - Apr 2009


  • Craniopharyngiomas
  • Radiosurgery
  • Radiotherapy
  • Stereotactic radiotherapy
  • Surgery
  • Toxicity

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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