Abstract
The optimal management of craniopharyngiomas remains controversial. The first-line treatment usually consists of surgical resection. Complete tumor removal provides a high rate of long-term control; however, aggressive surgery is associated with significant incidence of complications. Radiotherapy (RT) is currently used in patients after limited surgery and achieves excellent long-term tumor control. Stereotactic radiotherapy, both in the form of radiosurgery (RS) or fractionated stereotactic radiotherapy (FSRT), has been developed as a more accurate technique of irradiation with more precise tumor localization and consequently a reduction in the volume of normal brain irradiated to high radiation doses. We provide a review of published data on outcome of conventional fractionated RT and modern radiation techniques. FSRT is a suitable treatment technique for all sizes of craniopharyngiomas, and efficacy is comparable to conventional RT. Single-fraction stereotactic radiosurgery is usually delivered to small tumors away from critical structures. Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity.
Original language | English |
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Pages (from-to) | 125-132 |
Number of pages | 8 |
Journal | Neurosurgical Review |
Volume | 32 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2009 |
Keywords
- Craniopharyngiomas
- Radiosurgery
- Radiotherapy
- Stereotactic radiotherapy
- Surgery
- Toxicity
ASJC Scopus subject areas
- Clinical Neurology
- Surgery