The role of gastric accommodation in the pathophysiology of functional dyspepsia.

M. Di Stefano, E. Miceli, S. Mazzocchi, P. Tana, G. R. Corazza

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVES: The pathophysiology of functional dyspepsia is not yet completely known. Several mechanisms have been suggested as having a role in symptom onset and impaired gastric accommodation to meal is one of the most frequent. This review will focus on the pathophysiological and clinical aspects of this abnormality. EVIDENCE AND INFORMATION SOURCES: Medical peer-reviewed literature was considered to elucidate the role of gastric accommodation in the pathophysiology of functional dyspepsia. STATE OF THE ART: Impaired gastric accommodation to meal is present in around 40% of patients with functional dyspepsia and it was shown to be associated with the presence of early satiety. Unfortunately, a definitive treatment of this abnormality with fundus-relaxing drugs is not yet available. PERSPECTIVES: Further studies are needed to better clarify the role of each single pathophysiological mechanism on clinical manifestations of functional dyspepsia. Research is still ongoing to offer a valid therapeutic approach.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalEuropean Review for Medical and Pharmacological Sciences
Volume9
Issue number5 Suppl 1
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Pharmacology

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