The role of haemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer patients

M. Tampellini, A. Saini, I. Alabiso, R. Bitossi, M. P. Brizzi, C. M. Sculli, A. Berruti, G. Gorzegno, A. Magnino, E. Sperti, S. Miraglia, L. Forti, O. Alabiso, M. Aglietta, A. Harris, L. Dogliotti

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the study was to evaluate the influence of baseline haemoglobin level in predicting response to 5-fluorouracil (5FU)-based first-line chemotherapy in advanced colorectal cancer patients. Data from 631 patients were collected from three different institutions. Globally, overall response rate was 35.8% (226 out of 631). Factors influencing response rate were 5FU dose intensity (high: 43.1%, low: 34.0%, P=0.03); oxaliplatin (yes: 45.8%, no: 22.9%, P-1: 40.4%, -1: 29.2%, P=0.004). In subgroup analysis significant differences in response rate between anaemic and nonanaemic patients were recorded in those patients treated with infusional chemotherapies (45.7 vs 25.5%, P

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalBritish Journal of Cancer
Volume95
Issue number1
DOIs
Publication statusPublished - Jul 3 2006

Keywords

  • 5-fluorouracil
  • Activity
  • Anaemia
  • Colorectal neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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