Abstract
Viruses infect host cells releasing their genome (DNA or RNA) containing all information needed to replicate themselves. The viral genome takes control of the cells and helps the virus to evade the host immune system. Some viruses alter the functions of infected cells without killing them. In some cases infected cells lose control over normal cell proliferation and becomes cancerous. Viruses, such as HCMV and HIV-1, may leave their viral genome in the host cells for a certain period (latency) and begin to replicate when the cells are stressed causing diseases. HCMV and HIV-1 have developed multiple strategies to avoid recognition and elimination by the host's immune system. These strategies rely on viral products that mimic specific components of the host cells to prevent immune recognition of virally infected cells. In addition to viral proteins, viruses encode short non-coding RNAs (vmiRNAs) that regulate both viral and host cellular transcripts to favor viral infection and actively curtail the host's antiviral immune response. In this review, we will give an overview of the general functions of microRNAs generated by HCMV and HIV-1, their processing and interaction with the host's immune system.
| Original language | English |
|---|---|
| Article number | 689 |
| Journal | Frontiers in Microbiology |
| Volume | 8 |
| Issue number | APR |
| DOIs | |
| Publication status | Published - Apr 21 2017 |
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Keywords
- Cancer
- HCMV
- HIV
- Immune system
- MicroRNA
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
Cite this
The role of HCMV and HIV-1 MicroRNAs : Processing, and mechanisms of action during viral infection. / Fruci, Doriana; Rota, Rossella; Gallo, Angela.
In: Frontiers in Microbiology, Vol. 8, No. APR, 689, 21.04.2017.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - The role of HCMV and HIV-1 MicroRNAs
T2 - Processing, and mechanisms of action during viral infection
AU - Fruci, Doriana
AU - Rota, Rossella
AU - Gallo, Angela
PY - 2017/4/21
Y1 - 2017/4/21
N2 - Viruses infect host cells releasing their genome (DNA or RNA) containing all information needed to replicate themselves. The viral genome takes control of the cells and helps the virus to evade the host immune system. Some viruses alter the functions of infected cells without killing them. In some cases infected cells lose control over normal cell proliferation and becomes cancerous. Viruses, such as HCMV and HIV-1, may leave their viral genome in the host cells for a certain period (latency) and begin to replicate when the cells are stressed causing diseases. HCMV and HIV-1 have developed multiple strategies to avoid recognition and elimination by the host's immune system. These strategies rely on viral products that mimic specific components of the host cells to prevent immune recognition of virally infected cells. In addition to viral proteins, viruses encode short non-coding RNAs (vmiRNAs) that regulate both viral and host cellular transcripts to favor viral infection and actively curtail the host's antiviral immune response. In this review, we will give an overview of the general functions of microRNAs generated by HCMV and HIV-1, their processing and interaction with the host's immune system.
AB - Viruses infect host cells releasing their genome (DNA or RNA) containing all information needed to replicate themselves. The viral genome takes control of the cells and helps the virus to evade the host immune system. Some viruses alter the functions of infected cells without killing them. In some cases infected cells lose control over normal cell proliferation and becomes cancerous. Viruses, such as HCMV and HIV-1, may leave their viral genome in the host cells for a certain period (latency) and begin to replicate when the cells are stressed causing diseases. HCMV and HIV-1 have developed multiple strategies to avoid recognition and elimination by the host's immune system. These strategies rely on viral products that mimic specific components of the host cells to prevent immune recognition of virally infected cells. In addition to viral proteins, viruses encode short non-coding RNAs (vmiRNAs) that regulate both viral and host cellular transcripts to favor viral infection and actively curtail the host's antiviral immune response. In this review, we will give an overview of the general functions of microRNAs generated by HCMV and HIV-1, their processing and interaction with the host's immune system.
KW - Cancer
KW - HCMV
KW - HIV
KW - Immune system
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=85018278525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018278525&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2017.00689
DO - 10.3389/fmicb.2017.00689
M3 - Short survey
AN - SCOPUS:85018278525
VL - 8
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
SN - 1664-302X
IS - APR
M1 - 689
ER -