The role of Helicobacter pylori LPS in the pathogenesis of H. pylori-related gastropathy

E. Jirillo, S. Pece, N. M. Pellegrino, A. Di Leo, F. Russo, M. Linsalata, C. Messa, L. Amati, L. Caradonna, A. P. Moran, D. Caccavo

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Helicobacter pylori strains and/or their lipopolysaccharides (LPS) represent the trigger of different regional and systemic immune responses in the course of H. pylori-related gastropathy as indicated by the following: (i) in patients with chronic gastritis (CG) or duodenal ulcer (DU), eradication of H. pylori leads to a dramatic decrease of gastric mucosal content of various cytokines such as interleukin-1β and transforming growth factor-β1; (ii) gastric epithelial cells are activated by H. pylori organisms through tyrosine phosphorylation signaling events but H. pylori LPSs do not affect this signal transduction pathway; and (iii) in sera from patients with CG and DU, besides antibodies to S-form LPS, humoral IgG and IgA response against R-form LPS has been also detected. On the other hand, antibodies against synthetic polymeric Lewisx were found in a few patients with CG and in no patients with DU.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalInnate Immunity
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Immunology
  • Microbiology
  • Infectious Diseases


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