The role of HLA-G in immunity and hematopoiesis

Edgardo D. Carosella, Silvia Gregori, Nathalie Rouas-Freiss, Joel Lemaoult, Catherine Menier, Benoit Favier

Research output: Contribution to journalArticlepeer-review

Abstract

The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.

Original languageEnglish
Pages (from-to)353-368
Number of pages16
JournalCellular and Molecular Life Sciences
Volume68
Issue number3
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Angiogenesis
  • Dimers
  • Erythroid progenitors
  • Haematopoiesis
  • HLA-G
  • ILT
  • Immunological synapse
  • Regulatory cells
  • Trogocytosis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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