The role of hyperglycaemia-induced alterations of antithrombin III and factor X activation in the thrombin hyperactivity of Diabetes mellitus

A. Ceriello, A. Quatraro, E. Marchi, M. Barbanti, P. Dello Russo, P. Lefebvre, D. Giugliano

Research output: Contribution to journalArticlepeer-review

Abstract

Factor X concentration and factor X activation, antithrombin III anti-Xa activity and plasma concentration, and fibrinopeptide A were measured in 20 diabetic patients and 20 normal subjects. Although factor X activation (81.3 ± 2.2 vs 97.3 ± 2.1%, p <0.01; mean ± SE) and antithrombin III activity (76.5 ± 2.2 vs 96.3 ± 1.8%, p <0.01) were reduced in the diabetic patients, fibrinopeptide A concentration was increased (3.7 ± 0.4 vs 1.7 ± 0.2 ng ml-1, p <0.01). The ratio of factor X activation to antithrombin III anti-factor Xa activity was increased in the diabetic patients (1.10 ± 0.01 vs 1.01 ± 0.02, p <0.01). Induced hyperglycaemia was able to mimic all these abnormalities, without changing factor X or antithrombin III concentration. The results suggest that in vivo hyperglycaemia produces a decrease of factor X activation, but at the same time increases fibrinopeptide A formation due to a greater decrease of antithrombin III anti-Xa activity.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalDiabetic Medicine
Volume7
Issue number4
Publication statusPublished - 1990

Keywords

  • antithrombin III
  • diabetes
  • factor X
  • hypercoagulability
  • hyperglycaemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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