Abstract
Factor X concentration and factor X activation, antithrombin III anti-Xa activity and plasma concentration, and fibrinopeptide A were measured in 20 diabetic patients and 20 normal subjects. Although factor X activation (81.3 ± 2.2 vs 97.3 ± 2.1%, p <0.01; mean ± SE) and antithrombin III activity (76.5 ± 2.2 vs 96.3 ± 1.8%, p <0.01) were reduced in the diabetic patients, fibrinopeptide A concentration was increased (3.7 ± 0.4 vs 1.7 ± 0.2 ng ml-1, p <0.01). The ratio of factor X activation to antithrombin III anti-factor Xa activity was increased in the diabetic patients (1.10 ± 0.01 vs 1.01 ± 0.02, p <0.01). Induced hyperglycaemia was able to mimic all these abnormalities, without changing factor X or antithrombin III concentration. The results suggest that in vivo hyperglycaemia produces a decrease of factor X activation, but at the same time increases fibrinopeptide A formation due to a greater decrease of antithrombin III anti-Xa activity.
Original language | English |
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Pages (from-to) | 343-348 |
Number of pages | 6 |
Journal | Diabetic Medicine |
Volume | 7 |
Issue number | 4 |
Publication status | Published - 1990 |
Keywords
- antithrombin III
- diabetes
- factor X
- hypercoagulability
- hyperglycaemia
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine