The role of IL-1 gene cluster in longevity: A study in Italian population

Luca Cavallone, Massimiliano Bonafè, Fabiola Olivieri, Maurizio Cardelli, Francesca Marchegiani, Simona Giovagnetti, Grazia Di Stasio, Claudia Giampieri, Elena Mugianesi, Rosalia Stecconi, Francesca Sciacca, Luigi Maria Grimaldi, Giovanna De Benedictis, Domenico Lio, Calogero Caruso, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review


In this study, we analysed the polymorphic variants of IL-1α (C-T transition at position -889), IL-1β (C-T transition at position -511) and IL-1 receptor antagonist (Ra) (86-bp repeated sequence in intron 2) in 1131 subjects (453 females and 678 males) from Northern and Central Italy, including 134 centenarians, to evaluate whether IL-1 cluster alleles might be differently represented in people selected for longevity. In addition, IL-1Ra and IL-1β plasma levels were quantified by ELISA in 130 randomly selected subjects. No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects. IL-1Ra plasma levels showed an age-related increase, whereas IL-1β plasma levels did not show any detectable age-related trend. Neither IL-1Ra nor IL-1β plasma levels showed any relationship with genotypes of the three IL-1 genes. These results suggest that no one particular polymorphism in the IL-1 gene cluster yields an advantage for survival in the last decades of life, and that the age-related increase in plasma levels of IL-1Ra seems not to be genetically regulated but a likely safeguard mechanism to buffer the age-associated increased inflammatory state.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalMechanisms of Ageing and Development
Issue number4
Publication statusPublished - Apr 1 2003


  • Centenarians
  • IL-1
  • Immunogenetics
  • Longevity

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience


Dive into the research topics of 'The role of IL-1 gene cluster in longevity: A study in Italian population'. Together they form a unique fingerprint.

Cite this