The role of imaging in juvenile idiopathic arthritis

Clara Malattia, Mariangela Rinaldi, Alberto Martini

Research output: Contribution to journalReview articlepeer-review


Introduction: The prognosis of juvenile idiopathic arthritis (JIA) has changed dramatically due to the availability of novel drugs. Prompt diagnosis and treatment are essential to prevent permanent joint damage. As a result, methods to improve JIA diagnosis and prognosis are of high priority to tailor treatment strategies and maximize their efficacy. Musculoskeletal ultrasound and magnetic resonance imaging are more sensitive than clinical examination and radiography in the detection of joint involvement and might play a substantial role to optimize the management of JIA. Areas covered: This review compiles an inventory of potential uses of imaging studies in the modern practice of pediatric rheumatology, together with a critical analysis of the major challenges that are still to be addressed. Imaging appearance of normal growth-related changes of the musculoskeletal system will be discussed. Expert commentary: Knowledge of the evolving patterns of skeletal maturity is paramount to define pathological findings and avoid misinterpretations. Establishing a novel radiological algorithm for a rational use of imaging in JIA is of high priority to allow a speedier integration of imaging into the clinical workflow and decision-making process.

Original languageEnglish
Pages (from-to)681-694
Number of pages14
JournalExpert Review of Clinical Immunology
Issue number8
Publication statusPublished - Aug 3 2018


  • Conventional Radiography
  • Growing skeleton
  • Imaging outcome measures
  • Juvenile idiopathic arthritis
  • Magnetic Resonance Imaging
  • Musculoskeletal Ultrasound
  • Remission
  • Structural damage progression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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