The role of imaging in the skeletal involvement of mucopolysaccharidoses

Vincenzo Spina, Domenico Barbuti, Alberto Gaeta, Stefano Palmucci, Ernesto Soscia, Marco Grimaldi, Antonio Leone, Renzo Manara, Gabriele Polonara

Research output: Contribution to journalReview article


This article discusses the role of imaging modalities including radiography, multi-detector computed tomography, magnetic resonance imaging, and ultrasound in diagnosing and monitoring skeletal abnormalities in mucopolysaccharidoses (MPS). The advantages and disadvantages of these different imaging tools will be discussed, along with their feasibility in this class of patients. As the musculoskeletal involvement is common to all MPS and is one of the main reasons for seeking medical attention, an increased awareness among paediatricians, rheumatologists, orthopaedists, radiologists, and other musculoskeletal specialists on the possible spectrum of abnormalities observed could facilitate a timely diagnosis, an appropriate severity evaluation, and better management.

Original languageEnglish
Number of pages1
JournalItalian Journal of Pediatrics
Publication statusPublished - Nov 16 2018



  • Magnetic resonance imaging
  • Mucopolysaccharidoses
  • Multidetector computed tomography
  • Musculoskeletal involvement
  • Radiography
  • Ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Spina, V., Barbuti, D., Gaeta, A., Palmucci, S., Soscia, E., Grimaldi, M., Leone, A., Manara, R., & Polonara, G. (2018). The role of imaging in the skeletal involvement of mucopolysaccharidoses. Italian Journal of Pediatrics, 44.