TY - JOUR
T1 - The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance
T2 - Focus on hematology
AU - Curti, Antonio
AU - Trabanelli, Sara
AU - Salvestrini, Valentina
AU - Baccarani, Michele
AU - Lemoli, Roberto M.
PY - 2009/3/12
Y1 - 2009/3/12
N2 - The regulation of the interaction between the immune system and antigens, which may lead to the induction of immune tolerance, is critical both under physiologic conditions and in different pathological settings. In the past few years, major strides have been made in our understanding of the molecular and cellular bases of this process. Novel pathways have been identified and several novel therapeutic agents are currently under clinical investigation for those diseases in which the normal balance between activation and suppression of the immune response is altered. The tryptophan catabolic enzyme, indoleamine 2,3- dioxygenase (IDO), is one of the key players involved in the inhibition of cell proliferation, including that of activated T cells. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infection, pregnancy, transplantation, autoimmunity, and neoplasias, including hematologic malignancies. In this review, the role of IDO in the induction of immunologic tolerance is addressed with a specific focus on its recently discovered effect on hematologic malignancies.
AB - The regulation of the interaction between the immune system and antigens, which may lead to the induction of immune tolerance, is critical both under physiologic conditions and in different pathological settings. In the past few years, major strides have been made in our understanding of the molecular and cellular bases of this process. Novel pathways have been identified and several novel therapeutic agents are currently under clinical investigation for those diseases in which the normal balance between activation and suppression of the immune response is altered. The tryptophan catabolic enzyme, indoleamine 2,3- dioxygenase (IDO), is one of the key players involved in the inhibition of cell proliferation, including that of activated T cells. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infection, pregnancy, transplantation, autoimmunity, and neoplasias, including hematologic malignancies. In this review, the role of IDO in the induction of immunologic tolerance is addressed with a specific focus on its recently discovered effect on hematologic malignancies.
UR - http://www.scopus.com/inward/record.url?scp=63849112500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849112500&partnerID=8YFLogxK
U2 - 10.1182/blood-2008-07-144485
DO - 10.1182/blood-2008-07-144485
M3 - Article
C2 - 19023117
AN - SCOPUS:63849112500
VL - 113
SP - 2394
EP - 2401
JO - Blood
JF - Blood
SN - 0006-4971
IS - 11
ER -