The role of infection in Kawasaki syndrome

Nicola Principi, Donato Rigante, Susanna Esposito

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objectives: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). Methods: PubMed was searched for all of the studies published over the last 15 years using the key words "Kawasaki syndrome" or "mucocutaneous lymph node syndrome" and "infectious disease" or "genetics" or "vasculitis" or "pathogenesis". Results: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. Conclusions: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Infection
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Mucocutaneous Lymph Node Syndrome
Infection
Communicable Diseases
Genetic Polymorphisms
Vasculitis
PubMed
Viruses
Bacteria

Keywords

  • Children
  • Genetic susceptibility
  • Infectious disease
  • Kawasaki syndrome

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

The role of infection in Kawasaki syndrome. / Principi, Nicola; Rigante, Donato; Esposito, Susanna.

In: Journal of Infection, Vol. 67, No. 1, 07.2013, p. 1-10.

Research output: Contribution to journalArticle

Principi, N, Rigante, D & Esposito, S 2013, 'The role of infection in Kawasaki syndrome', Journal of Infection, vol. 67, no. 1, pp. 1-10. https://doi.org/10.1016/j.jinf.2013.04.004
Principi, Nicola ; Rigante, Donato ; Esposito, Susanna. / The role of infection in Kawasaki syndrome. In: Journal of Infection. 2013 ; Vol. 67, No. 1. pp. 1-10.
@article{b2a4f66598ac4bf8a9032de2fedbbead,
title = "The role of infection in Kawasaki syndrome",
abstract = "Objectives: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). Methods: PubMed was searched for all of the studies published over the last 15 years using the key words {"}Kawasaki syndrome{"} or {"}mucocutaneous lymph node syndrome{"} and {"}infectious disease{"} or {"}genetics{"} or {"}vasculitis{"} or {"}pathogenesis{"}. Results: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. Conclusions: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease.",
keywords = "Children, Genetic susceptibility, Infectious disease, Kawasaki syndrome",
author = "Nicola Principi and Donato Rigante and Susanna Esposito",
year = "2013",
month = "7",
doi = "10.1016/j.jinf.2013.04.004",
language = "English",
volume = "67",
pages = "1--10",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - The role of infection in Kawasaki syndrome

AU - Principi, Nicola

AU - Rigante, Donato

AU - Esposito, Susanna

PY - 2013/7

Y1 - 2013/7

N2 - Objectives: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). Methods: PubMed was searched for all of the studies published over the last 15 years using the key words "Kawasaki syndrome" or "mucocutaneous lymph node syndrome" and "infectious disease" or "genetics" or "vasculitis" or "pathogenesis". Results: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. Conclusions: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease.

AB - Objectives: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). Methods: PubMed was searched for all of the studies published over the last 15 years using the key words "Kawasaki syndrome" or "mucocutaneous lymph node syndrome" and "infectious disease" or "genetics" or "vasculitis" or "pathogenesis". Results: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. Conclusions: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease.

KW - Children

KW - Genetic susceptibility

KW - Infectious disease

KW - Kawasaki syndrome

UR - http://www.scopus.com/inward/record.url?scp=84878366030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878366030&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2013.04.004

DO - 10.1016/j.jinf.2013.04.004

M3 - Article

VL - 67

SP - 1

EP - 10

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 1

ER -