TY - JOUR
T1 - The role of inflammation in diabetic retinopathy
T2 - a review
AU - Taurone, S.
AU - Ralli, M.
AU - Nebbioso, M.
AU - Greco, A.
AU - Artico, M.
AU - Attanasio, G.
AU - Gharbiya, M.
AU - Plateroti, A. M.
AU - Zamai, L.
AU - Micera, A.
N1 - Funding Information:
This paper was financially supported by Ministry of Health and Fondazione Roma.
Publisher Copyright:
© 2020 Verduci Editore s.r.l. All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - – OBJECTIVE: Diabetic retinopathy and diabetes represent serious health conditions, being considered among the main causes of blindness. In recent years, anti-VEGF therapies have been of great help in the treatment of retinal pathology and, until now, they represent the primary choice therapy for diabetic retinopathy. Nevertheless, many patients do not experience significant benefits of vision after an anti-VEGF monotherapy. For this reason, several researchers recently focused their attention on the mechanisms that play a central role in the development and progression of diabetic retinopathy. RESULTS: Available scientific evidence confirms that diabetic retinopathy requires other molecules capable of modifying the mechanisms that, together with angiogenesis, contribute to the development of the condition, such as vascular and neuroinflammation. CONCLUSIONS: This review summarizes the current knowledge of the pathological changes that occur in diabetic retinopathy and that might contribute to identify possible new strategies for the treatment of this condition.
AB - – OBJECTIVE: Diabetic retinopathy and diabetes represent serious health conditions, being considered among the main causes of blindness. In recent years, anti-VEGF therapies have been of great help in the treatment of retinal pathology and, until now, they represent the primary choice therapy for diabetic retinopathy. Nevertheless, many patients do not experience significant benefits of vision after an anti-VEGF monotherapy. For this reason, several researchers recently focused their attention on the mechanisms that play a central role in the development and progression of diabetic retinopathy. RESULTS: Available scientific evidence confirms that diabetic retinopathy requires other molecules capable of modifying the mechanisms that, together with angiogenesis, contribute to the development of the condition, such as vascular and neuroinflammation. CONCLUSIONS: This review summarizes the current knowledge of the pathological changes that occur in diabetic retinopathy and that might contribute to identify possible new strategies for the treatment of this condition.
KW - Anti-VEGF therapy
KW - Diabetes
KW - Diabetic retinopathy
KW - Neuroinflammation
UR - http://www.scopus.com/inward/record.url?scp=85095759870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095759870&partnerID=8YFLogxK
U2 - 10.26355/eurrev_202010_23379
DO - 10.26355/eurrev_202010_23379
M3 - Article
C2 - 33155187
AN - SCOPUS:85095759870
VL - 24
SP - 10319
EP - 10329
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
IS - 20
ER -