The role of inflammation in patients with intraductal mucinous neoplasm of the pancreas and in those with pancreatic adenocarcinoma

Raffaele Pezzilli, Massimiliano M. Corsi, Alessandra Barassi, Antonio M. Morselli-Labate, Giada Dogliotti, Riccardo Casadei, Roberto Corinaldesi, Gianvico Melzi D'Eril

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There are very few data regarding inflammation in patients with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Aim: To evaluate the circulating concentrations of placental growth factor (PlGF), transforming growth factor-alpha (TGF-α), transforming growth factor-beta 1 (TGF-β1), tumour necrosis factor receptor 1 (TNF-R1) and matrix metalloproteinase-2 (MMP-2) in patients with IPMNs and in those with pancreatic adenocarcinomas. Patients and Methods: Sixty-nine patients were enrolled: 23 (33.3%) had IPMNs and 46 (66.7%) had histologically confirmed pancreatic adenocarcinomas. Thirteen healthy subjects were also studied. PlGF, TGF-α, TGF-β1, TNF-R1 and MMP-2 were determined using commercially available kits. Results: TNF-R1 (p=0.003) was the only protein significantly different among the three groups. Conclusion: Serum TNF-R1 was elevated in patients with IPMNs and in those with pancreatic adenocarcinomas, suggesting a high apoptotic activity in both groups of patients studied.

Original languageEnglish
Pages (from-to)3801-3805
Number of pages5
JournalAnticancer Research
Volume30
Issue number9
Publication statusPublished - 2010

Keywords

  • Matrix metalloproteinase-2
  • Pancreatic neoplasms
  • Placental growth factor
  • Transforming growth factor-alpha
  • Transforming growth factor-beta 1
  • Tumour necrosis factor receptor 1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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