The role of inflammatory cells in angiogenesis in multiple myeloma

Domenico Ribatti, Angelo Vacca

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, via production and release of a large spectrum of pro-angiogenic mediators, thus creating the specific microenvironment that favors increased rate of tissue vascularization. In this article, we focus on the immune cell component of the angiogenic process occurring during multiple myeloma progression. We also provide information on some anti-angiogenic properties of immune cells that may be applied for a potential pharmacological use as anti-angiogenic agents in the disease treatment.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages361-376
Number of pages16
Volume816
DOIs
Publication statusPublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume816
ISSN (Print)00652598
ISSN (Electronic)22148019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Ribatti, D., & Vacca, A. (2014). The role of inflammatory cells in angiogenesis in multiple myeloma. In Advances in Experimental Medicine and Biology (Vol. 816, pp. 361-376). (Advances in Experimental Medicine and Biology; Vol. 816). https://doi.org/10.1007/978-3-0348-0837-8-14