TY - JOUR
T1 - The role of inflammatory mediators in epilepsy
T2 - Focus on developmental and epileptic encephalopathies and therapeutic implications
AU - Orsini, Alessandro
AU - Foiadelli, Thomas
AU - Costagliola, Giorgio
AU - Michev, Alexandre
AU - Consolini, Rita
AU - Vinci, Federica
AU - Peroni, Diego
AU - Striano, Pasquale
AU - Savasta, Salvatore
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5
Y1 - 2021/5
N2 - In recent years, there has been an increasing interest in the potential involvement of neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity (that includes cytokines and chemokines) has been extensively investigated either in animal models of epilepsy and in clinical settings. Developmental and epileptic encephalopathies (DEE) are a heterogeneous group of epileptic disorders, in which uncontrolled epileptic activity results in cognitive, motor and behavioral impairment. By definition, epilepsy in DEE is poorly controlled by common antiepileptic drugs but may respond to alternative treatments, including steroids and immunomodulatory drugs. In this review, we will focus on how cytokines and chemokines play a role in the pathogenesis of DEE and why expanding our knowledge about the role of neuroinflammation in DEE may be crucial to develop new and effective targeted therapeutic strategies to prevent seizure recurrence and developmental regression.
AB - In recent years, there has been an increasing interest in the potential involvement of neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity (that includes cytokines and chemokines) has been extensively investigated either in animal models of epilepsy and in clinical settings. Developmental and epileptic encephalopathies (DEE) are a heterogeneous group of epileptic disorders, in which uncontrolled epileptic activity results in cognitive, motor and behavioral impairment. By definition, epilepsy in DEE is poorly controlled by common antiepileptic drugs but may respond to alternative treatments, including steroids and immunomodulatory drugs. In this review, we will focus on how cytokines and chemokines play a role in the pathogenesis of DEE and why expanding our knowledge about the role of neuroinflammation in DEE may be crucial to develop new and effective targeted therapeutic strategies to prevent seizure recurrence and developmental regression.
KW - Chemokine
KW - Cytokine
KW - Epilepsy
KW - Neuroinflammation
KW - Steroid
KW - West syndrome
UR - http://www.scopus.com/inward/record.url?scp=85102249212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102249212&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2021.106588
DO - 10.1016/j.eplepsyres.2021.106588
M3 - Review article
AN - SCOPUS:85102249212
VL - 172
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
M1 - 106588
ER -