TY - JOUR
T1 - The role of integrins in immune-mediated diseases of the nervous system
AU - Archelos, Juan J.
AU - Previtali, Stefano C.
AU - Hartung, Hans Peter
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Immune-mediated diseases of the CNS and PNS, such as multiple sclerosis and Guillain-Barre syndrome, respectively, constitute a major cause of transient and permanent neurological disability in the adult. The aetiology and pathogenesis of these disorders are only partially understood. On a cellular level, focal mononuclear-cell infiltration with demyelination and eventual axonal loss is a crucial pathogenetic event that leads to inflammation and subsequent dysfunction. Here, the evidence that integrins, a family of cell adhesion molecules, expressed on neural and immune cells might play a central role in immune cell recruitment to the CNS and PNS, and probably in tissue repair is reviewed. Distinct integrin expression patterns are observed in multiple sclerosis and Guillain-Barre syndrome. Therapeutic targeting of integrins has been very successful in the corresponding animal models and holds promise as a novel treatment strategy to combat human immune-mediated disorders of the nervous system.
AB - Immune-mediated diseases of the CNS and PNS, such as multiple sclerosis and Guillain-Barre syndrome, respectively, constitute a major cause of transient and permanent neurological disability in the adult. The aetiology and pathogenesis of these disorders are only partially understood. On a cellular level, focal mononuclear-cell infiltration with demyelination and eventual axonal loss is a crucial pathogenetic event that leads to inflammation and subsequent dysfunction. Here, the evidence that integrins, a family of cell adhesion molecules, expressed on neural and immune cells might play a central role in immune cell recruitment to the CNS and PNS, and probably in tissue repair is reviewed. Distinct integrin expression patterns are observed in multiple sclerosis and Guillain-Barre syndrome. Therapeutic targeting of integrins has been very successful in the corresponding animal models and holds promise as a novel treatment strategy to combat human immune-mediated disorders of the nervous system.
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U2 - 10.1016/S0166-2236(98)01287-9
DO - 10.1016/S0166-2236(98)01287-9
M3 - Article
C2 - 10088997
AN - SCOPUS:0033033953
VL - 22
SP - 30
EP - 38
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 1
ER -