The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies

Iris Dotan, Matthieu Allez, Silvio Danese, Mary Keir, Swati Tole, Jacqueline McBride

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation in the gastrointestinal tract. The underlying pathobiology of IBD includes an increase in infiltrating gut-homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise process involving multiple integrins and adhesion molecules expressed on endothelial cells, the distinct roles of integrin-expressing immune cells is not fully understood in the pathology of IBD. In this review, we detail the involvement of integrins expressed on specific lymphocyte subsets in the pathogenesis of IBD and discuss the current status of approved and investigational integrin-targeted therapies.

Original languageEnglish
Pages (from-to)245-262
Number of pages18
JournalMedicinal Research Reviews
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 2020

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