The role of interleukin-13 in chronic inflammatory intestinal disorders

Research output: Contribution to journalReview article

Abstract

Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some intestinal disorders. IL-13 is produced by Th2 cells, natural killer T cell, innate lymphoid cells and innate immune cells, which contribute to trigger and maintain a chronic idiopathic intestinal inflammation. In murine models IL-13 exerts pleiotropic functions, playing either pathogenic or protective roles according to the different experimental conditions. As regards celiac disease, IL-13 is considered to be involved mostly in the refractory phase rather than at uncomplicated stage. Discrepancies have been observed in the role of IL-13 upon the inflammation and fibrosis in ulcerative colitis (UC) and in Crohn's disease, respectively. Failure of the anti-IL-13 monoclonal antibodies tralokinumab and anrukinzumab in UC patients in clinical trials support the absence of a role for IL-13 in UC. This review deals with IL-13 in several experimental colitis models -such as oxazolone-, trinitrobenzene sulfonic acid- or dextran sodium sulphate-induced colitis- and chronic intestinal inflammatory disorders -including celiac disease, UC and Crohn's disease-, and it also highlights the attempts to modulate IL-13 as therapeutic tool.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalAutoimmunity Reviews
Volume18
Issue number5
DOIs
Publication statusPublished - May 2019

Keywords

  • Animals
  • Chronic Disease
  • Humans
  • Immunity, Innate/physiology
  • Inflammatory Bowel Diseases/etiology
  • Interleukin-13/physiology
  • Intestinal Mucosa/immunology
  • Lymphocytes/physiology
  • Mice
  • Natural Killer T-Cells/immunology
  • Th2 Cells/immunology

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