The role of interleukin-6 (IL-6) in the proliferation and differentiation of human neural stem cells

Stefano F. Pagano, Sabrina Lucchiari, Alessandra Bez, Dario Ponti, Marco Onofrj, Francesco Vitello, Yvan Torrente, Sabrina Etteri, Valeria Di Giorgi, Augusto Colombo, Nereo Bresolin, Marina Girelli, Lidia Cova, Eugenio A. Parati

Research output: Contribution to journalArticlepeer-review


The proliferation of human embryonic and adult stem cells is controlled by extrinsic factors such as epidermal growth factor (EGF) and fibroblast growth factor (bFGF). Their differentiation, instead, is clearly determined by a family of neuropoietic factors including ciliary neurotrophic factor (CNTF), leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). The results of this study show the capability of the interleukin-6 to delay the differentiation processes and to improve significantly the proliferation condition of embryonic neural stem cells. Besides, clonal analysis shows that the self-renewing capacity and the multipotentiality of human neural stem cells are not modified by the presence of IL-6 during early and later culture passages. This is an important demonstration of the high clonogenic potential of IL-6 in human embryonic neural stem cells (heCNS-SC), whose capacity to secrete IL-6 we have ,finally, demonstrated.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalNeuroscience Research Communications
Issue number1
Publication statusPublished - 2001


  • Differentiation
  • Interleuchine-6 (IL-6)
  • Neural stem cells
  • Proliferation

ASJC Scopus subject areas

  • Neuroscience(all)


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