The role of intravascular ultrasound and quantitative angiography in the functional assessment of intermediate coronary lesions: Correlation with fractional flow reserve

Toru Naganuma, Azeem Latib, Charis Costopoulos, Kensuke Takagi, Charbel Naim, Katsumasa Sato, Tadashi Miyazaki, Masanori Kawaguchi, Vasileios F. Panoulas, Sandeep Basavarajaiah, Filippo Figini, Alaide Chieffo, Matteo Montorfano, Mauro Carlino, Antonio Colombo

Research output: Contribution to journalArticle

Abstract

Background: The correlation between fractional flow reserve (FFR) and intravascular ultrasound (IVUS) metrics including minimal lumen area (MLA), plaque burden and morphology remain a matter of debate. Methods: Between June 2008 and May 2013, 132 intermediate stenoses in 109 patients were assessed by FFR, IVUS and quantitative angiography. Receiver-operating characteristic (ROC) curve analyses were used to identify MLA/lesion length/plaque burden cut-off values predictive of FFR <0.80. Results: FFR 2 had 79.5% sensitivity, 76.3% specificity, 0.822 area under curve (AUC), 58.5% positive predictive value, 89.9% negative predictive value and 77.3% accuracy in predicting a positive FFR. In lesions with reference diameter vessel (RVD) ≥3.0mm, the MLA cut-off value was 2.84mm2 (sensitivity 72.2%, specificity 83.0%, AUC 0.842) whereas in lesions with RVD 2 (sensitivity 90.5%, specificity 69.6%, AUC 0.823). A moderate correlation was observed between MLA and FFR (r=0.429, p

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalCardiovascular Revascularization Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Fractional flow reserve
  • Intermediate lesions
  • Intravascular ultrasound
  • Plaque morphology
  • Quantitative coronary angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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