Abstract
Invariant NKT cells (iNKT) represent a unique subset of innate lymphocytes that play a dual role and exert a pro-inflammatory function and also a tolerogenic function that is crucial to maintain T cell tolerance and prevent autoimmune diseases like Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arhritis and Systemic Lupus Erithematosus (SLE). Although a large body of evidence indicated that iNKT cells are instrumental to counterregulate T cell-mediated autoimmune diseases, there is still some controversy on whether iNKT cells can actively induce immunosuppression and directly dampen T cell autoimmunity. Moreover, the recent discovery of a distinct iNKT cell subset, the iNKT17 cells, with strong adjuvant and pro-inflammatory function raised the question on what is the role of NKT17 cells in the pathogenesis of autoimmune diseases. Here, we review the current knowledge on iNKT cell biology and focus our attention on the possible mechanism of action and final effect of the different iNKT cell subsets in the pathogenesis of T cellmediated autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1240-1250 |
| Number of pages | 11 |
| Journal | Frontiers in Bioscience |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jun 1 2014 |
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Keywords
- Autoimmune diseases
- Cytokines
- Dendritic cells
- Immune tolerance
- Natural killer T cells
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
The role of invariant NKT cells in organ-specific autoimmunity. / Di Pietro, Caterina; Falcone, Marika.
In: Frontiers in Bioscience, Vol. 19, No. 8, 01.06.2014, p. 1240-1250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of invariant NKT cells in organ-specific autoimmunity
AU - Di Pietro, Caterina
AU - Falcone, Marika
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Invariant NKT cells (iNKT) represent a unique subset of innate lymphocytes that play a dual role and exert a pro-inflammatory function and also a tolerogenic function that is crucial to maintain T cell tolerance and prevent autoimmune diseases like Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arhritis and Systemic Lupus Erithematosus (SLE). Although a large body of evidence indicated that iNKT cells are instrumental to counterregulate T cell-mediated autoimmune diseases, there is still some controversy on whether iNKT cells can actively induce immunosuppression and directly dampen T cell autoimmunity. Moreover, the recent discovery of a distinct iNKT cell subset, the iNKT17 cells, with strong adjuvant and pro-inflammatory function raised the question on what is the role of NKT17 cells in the pathogenesis of autoimmune diseases. Here, we review the current knowledge on iNKT cell biology and focus our attention on the possible mechanism of action and final effect of the different iNKT cell subsets in the pathogenesis of T cellmediated autoimmune diseases.
AB - Invariant NKT cells (iNKT) represent a unique subset of innate lymphocytes that play a dual role and exert a pro-inflammatory function and also a tolerogenic function that is crucial to maintain T cell tolerance and prevent autoimmune diseases like Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arhritis and Systemic Lupus Erithematosus (SLE). Although a large body of evidence indicated that iNKT cells are instrumental to counterregulate T cell-mediated autoimmune diseases, there is still some controversy on whether iNKT cells can actively induce immunosuppression and directly dampen T cell autoimmunity. Moreover, the recent discovery of a distinct iNKT cell subset, the iNKT17 cells, with strong adjuvant and pro-inflammatory function raised the question on what is the role of NKT17 cells in the pathogenesis of autoimmune diseases. Here, we review the current knowledge on iNKT cell biology and focus our attention on the possible mechanism of action and final effect of the different iNKT cell subsets in the pathogenesis of T cellmediated autoimmune diseases.
KW - Autoimmune diseases
KW - Cytokines
KW - Dendritic cells
KW - Immune tolerance
KW - Natural killer T cells
KW - Review
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U2 - 10.2741/4279
DO - 10.2741/4279
M3 - Article
C2 - 24896348
AN - SCOPUS:84904559470
VL - 19
SP - 1240
EP - 1250
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - 8
ER -