The role of ionic strength on the enhancement of the hemolytic activity of sticholysin I, a cytolysin from Stichodactyla helianthus

C. Alvarez, M. E. Lanio, M. Tejuca, D. Martínez, F. Pazos, A. M. Campos, M. V. Encinas, T. Pertinhez, S. Schreier, E. A. Lissi

Research output: Contribution to journalArticle

Abstract

Sticholysin I (St I) is a potent cytolytic polypeptide purified from the Caribbean sea anemone Stichodactyla helianthus. The hemolytic activity of sticholysin is potentiated by its preincubation at high ionic strengths. In the present work the mechanism of the potentiating action of the medium ionic strength on the toxin hemolytic capacity is investigated. It is suggested that preincubation with high saline concentration induces a transition of St I to a more relaxed conformation that facilitates the lytic process.

Original languageEnglish
Pages (from-to)165-178
Number of pages14
JournalToxicon
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Toxicology

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    Alvarez, C., Lanio, M. E., Tejuca, M., Martínez, D., Pazos, F., Campos, A. M., Encinas, M. V., Pertinhez, T., Schreier, S., & Lissi, E. A. (1998). The role of ionic strength on the enhancement of the hemolytic activity of sticholysin I, a cytolysin from Stichodactyla helianthus. Toxicon, 36(1), 165-178. https://doi.org/10.1016/S0041-0101(97)00069-X