The role of iron in gray matter degeneration in huntington's disease: A magnetic resonance imaging study

Cristina Sánchez-Castañeda, Ferdinando Squitieri, Margherita Di Paola, Michael Dayan, Martina Petrollini, Umberto Sabatini

Research output: Contribution to journalArticlepeer-review

Abstract

In Huntington's disease, iron accumulation in basal ganglia accompanies neuronal loss. However, if iron content changes with disease progression and how it relates to gray matter atrophy is not clear yet. We explored iron content in basal ganglia and cortex and its relationship with gray matter volume in 77 mutation carriers [19 presymptomatic, 8 with soft symptoms (SS), and 50 early-stage patients) and 73 matched-controls by T2*relaxometry and T1-weighted imaging on a 3T scanner. The ANCOVA model showed that iron accumulates in the caudate in presymptomatic subjects (P=0.004) and remains relatively stable along disease stages in this nucleus; while increases in putamen and globus pallidus (P

Original languageEnglish
Pages (from-to)50-66
Number of pages17
JournalHuman Brain Mapping
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Huntington's disease
  • Iron
  • MRI
  • Multimodal
  • Neuronal loss

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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