TY - CHAP
T1 - The role of JAM-A in inflammatory bowel disease
T2 - Unrevealing the ties that bind
AU - Vetrano, Stefania
AU - Danese, Silvio
PY - 2009/5
Y1 - 2009/5
N2 - Tight junctions (TJ) are junctional proteins whose function is to maintain an intact intestinal epithelial barrier and regulate the paracellular movement of water and solutes. Altered TJ structure and epithelial permeability are observed in inflammatory bowel disease and seem to have an important role in the pathogenesis of these diseases. Junctional adhesion molecule-A (JAM-A) is a protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. Its function at tight junctions appears to be crucial as an extracellular adhesive molecule in the direct regulation of intestinal barrier function. This review focuses on the role of JAM-A in controlling mucosal homeostasis by regulating the integrity and permeability of epithelial barrier function.
AB - Tight junctions (TJ) are junctional proteins whose function is to maintain an intact intestinal epithelial barrier and regulate the paracellular movement of water and solutes. Altered TJ structure and epithelial permeability are observed in inflammatory bowel disease and seem to have an important role in the pathogenesis of these diseases. Junctional adhesion molecule-A (JAM-A) is a protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. Its function at tight junctions appears to be crucial as an extracellular adhesive molecule in the direct regulation of intestinal barrier function. This review focuses on the role of JAM-A in controlling mucosal homeostasis by regulating the integrity and permeability of epithelial barrier function.
KW - Inflammatory bowel disease (IBD)
KW - Junctional adhesion molecule-A (JAM-A)
KW - Tight junctions
UR - http://www.scopus.com/inward/record.url?scp=67249112673&partnerID=8YFLogxK
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U2 - 10.1111/j.1749-6632.2009.04045.x
DO - 10.1111/j.1749-6632.2009.04045.x
M3 - Chapter
C2 - 19538321
AN - SCOPUS:67249112673
SN - 9781573317498
VL - 1165
T3 - Annals of the New York Academy of Sciences
SP - 308
EP - 313
BT - Annals of the New York Academy of Sciences
ER -