The role of KSRP in mRNA decay and microRNA precursor maturation

Roberto Gherzi, Ching Yi Chen, Michele Trabucchi, Andres Ramos, Paola Briata

Research output: Contribution to journalArticle

Abstract

KH-type splicing regulatory protein (KSRP)/FBP2, a single-strand nucleic acid binding protein originally identified as both an RNA-binding protein and a transcription factor, affects RNA fates at multiple levels. In this review we will discuss the ability of KSRP to (1) promote decay of labile mRNAs by interacting with some components of the mRNA decay machinery and (2) favor the maturation of a select group of microRNA precursors. We also discuss how its peculiar modular structure allows KSRP to specifically interact with a wide spectrum of RNA sequences and how post-translational modifications influence KSRP functions in cell proliferation and differentiation.

Original languageEnglish
Pages (from-to)230-239
Number of pages10
JournalWiley Interdisciplinary Reviews: RNA
Volume1
Issue number2
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Medicine(all)

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