The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: A consensus report

P. Cinque, G. M. Cleator, T. Weber, P. Monteyne, C. J. Sindic, A. M. Van Loon

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume61
Issue number4
Publication statusPublished - Oct 1996

Fingerprint

Herpes Simplex Encephalitis
Polymerase Chain Reaction
Virology
Clinical Laboratory Techniques
Human Herpesvirus 1
Nervous System
Antibody Formation
Early Diagnosis
Therapeutics
Recurrence
DNA
Infection

Keywords

  • Herpes encephalitis
  • Herpes simplex
  • Management
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis : A consensus report. / Cinque, P.; Cleator, G. M.; Weber, T.; Monteyne, P.; Sindic, C. J.; Van Loon, A. M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 61, No. 4, 10.1996, p. 339-345.

Research output: Contribution to journalArticle

@article{8f7c18534b7d48a495a3524fca6b726d,
title = "The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: A consensus report",
abstract = "As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described.",
keywords = "Herpes encephalitis, Herpes simplex, Management, Polymerase chain reaction",
author = "P. Cinque and Cleator, {G. M.} and T. Weber and P. Monteyne and Sindic, {C. J.} and {Van Loon}, {A. M.}",
year = "1996",
month = "10",
language = "English",
volume = "61",
pages = "339--345",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis

T2 - A consensus report

AU - Cinque, P.

AU - Cleator, G. M.

AU - Weber, T.

AU - Monteyne, P.

AU - Sindic, C. J.

AU - Van Loon, A. M.

PY - 1996/10

Y1 - 1996/10

N2 - As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described.

AB - As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described.

KW - Herpes encephalitis

KW - Herpes simplex

KW - Management

KW - Polymerase chain reaction

UR - http://www.scopus.com/inward/record.url?scp=0029905953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029905953&partnerID=8YFLogxK

M3 - Article

C2 - 8890768

AN - SCOPUS:0029905953

VL - 61

SP - 339

EP - 345

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 4

ER -