The Role of Laparoscopic Surgery in Localized Pancreatic Neuroendocrine Tumours.

Valentina Ferraro, Michele Tedeschi, Letizia Laera, Michele Ammendola, Umberto Riccelli, Nicola Silvestris, Alba Fiorentino, Giammarco Surico, Riccardo Inchingolo, Francesco Decembrino, Nicola de Angelis, Riccardo Memeo

Research output: Contribution to journalReview articlepeer-review


OPINION STATEMENT: Pancreatic neuroendocrine tumours (PNETs) are a rare and heterogeneous group of tumours with various clinical manifestations and biological behaviours. They represent approximately 2-4% of all pancreatic tumours, with an incidence of 2-3 cases per million people. PNETs are classified clinically as non-functional or functional, and pancreatic resection is recommended for lesions greater than 2 cm. The surgical approach can involve "typical" and "atypical" resections depending on the number, size and location of the tumour. Typical resections include pancreaticoduodenectomy, distal pancreatectomy enucleation and, rarely, total pancreatectomy. Atypical resections comprise central pancreatectomies or enucleations. Minimally invasive pancreatic resection has been proven to be technically feasible and safe in high-volume and specialized centres with highly skilled laparoscopic surgeons, with consolidated benefits for patients in the postoperative course. However, open and minimally invasive pancreatic surgery remains to have a high rate of complications; there is no specific technical contraindication to minimally invasive pancreatic surgery, but an appropriate patient selection is crucial to obtain satisfactory clinical and oncological outcomes.

Original languageEnglish
Article number27
JournalCurrent Treatment Options in Oncology
Issue number4
Publication statusPublished - Feb 27 2021


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