Abstract
Vagus nerve stimulation (VNS) is a useful tool for drug-resistant epilepsy, but it induces known laryngeal side effects, with a significant role on patients’ quality of life. VNS patients may show persistent left vocal fold (LVF) palsy at rest and/or recurrent LVF adduction during stimulation. This study aims at electromyographically evaluating laryngeal muscles abnormalities in VNS patients. We compared endoscopic laryngeal evaluation data in six VNS patients with laryngeal muscle electromyography (LMEMG) carried out on the thyroarytenoid, cricothyroid, posterior cricoarytenoid, and cricopharyngeal muscles. Endoscopy showed LVF palsy at rest in 3/6 patients in whom LMEMG documented a tonic spastic activity with reduced phasic modulation. In four out of six patients with recurrent LVF adduction during VNS activation, LMEMG showed a compound muscle action potential persisting for the whole stimulation. This is the first LMEMG report of VNS-induced motor unit activation via recurrent laryngeal nerve and upper laryngeal nerve stimulation. LMEMG data were could, therefore, be considered consistent with the endoscopic laryngeal examination in all patient.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | European Archives of Oto-Rhino-Laryngology |
| DOIs | |
| Publication status | Accepted/In press - Oct 13 2016 |
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Keywords
- Drug-resistant epilepsy
- Electrical stimulation
- Electromyography
- Manuscript
- Vocal cord paresis
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
The role of laryngeal electromyography in vagus nerve stimulation-related vocal fold dysmotility. / Saibene, Alberto M.; Zambrelli, Elena; Pipolo, Carlotta; Maccari, Alberto; Felisati, Giovanni; Felisati, Elena; Furia, Francesca; Vignoli, Aglaia; Canevini, Maria Paola; Alfonsi, Enrico.
In: European Archives of Oto-Rhino-Laryngology, 13.10.2016, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of laryngeal electromyography in vagus nerve stimulation-related vocal fold dysmotility
AU - Saibene, Alberto M.
AU - Zambrelli, Elena
AU - Pipolo, Carlotta
AU - Maccari, Alberto
AU - Felisati, Giovanni
AU - Felisati, Elena
AU - Furia, Francesca
AU - Vignoli, Aglaia
AU - Canevini, Maria Paola
AU - Alfonsi, Enrico
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Vagus nerve stimulation (VNS) is a useful tool for drug-resistant epilepsy, but it induces known laryngeal side effects, with a significant role on patients’ quality of life. VNS patients may show persistent left vocal fold (LVF) palsy at rest and/or recurrent LVF adduction during stimulation. This study aims at electromyographically evaluating laryngeal muscles abnormalities in VNS patients. We compared endoscopic laryngeal evaluation data in six VNS patients with laryngeal muscle electromyography (LMEMG) carried out on the thyroarytenoid, cricothyroid, posterior cricoarytenoid, and cricopharyngeal muscles. Endoscopy showed LVF palsy at rest in 3/6 patients in whom LMEMG documented a tonic spastic activity with reduced phasic modulation. In four out of six patients with recurrent LVF adduction during VNS activation, LMEMG showed a compound muscle action potential persisting for the whole stimulation. This is the first LMEMG report of VNS-induced motor unit activation via recurrent laryngeal nerve and upper laryngeal nerve stimulation. LMEMG data were could, therefore, be considered consistent with the endoscopic laryngeal examination in all patient.
AB - Vagus nerve stimulation (VNS) is a useful tool for drug-resistant epilepsy, but it induces known laryngeal side effects, with a significant role on patients’ quality of life. VNS patients may show persistent left vocal fold (LVF) palsy at rest and/or recurrent LVF adduction during stimulation. This study aims at electromyographically evaluating laryngeal muscles abnormalities in VNS patients. We compared endoscopic laryngeal evaluation data in six VNS patients with laryngeal muscle electromyography (LMEMG) carried out on the thyroarytenoid, cricothyroid, posterior cricoarytenoid, and cricopharyngeal muscles. Endoscopy showed LVF palsy at rest in 3/6 patients in whom LMEMG documented a tonic spastic activity with reduced phasic modulation. In four out of six patients with recurrent LVF adduction during VNS activation, LMEMG showed a compound muscle action potential persisting for the whole stimulation. This is the first LMEMG report of VNS-induced motor unit activation via recurrent laryngeal nerve and upper laryngeal nerve stimulation. LMEMG data were could, therefore, be considered consistent with the endoscopic laryngeal examination in all patient.
KW - Drug-resistant epilepsy
KW - Electrical stimulation
KW - Electromyography
KW - Manuscript
KW - Vocal cord paresis
UR - http://www.scopus.com/inward/record.url?scp=84991096939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991096939&partnerID=8YFLogxK
U2 - 10.1007/s00405-016-4344-3
DO - 10.1007/s00405-016-4344-3
M3 - Article
SP - 1
EP - 5
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
ER -