The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients

G. Ercolani, G. Vetrone, G. L. Grazi, M. Cescon, P. D I Gioia, M. Ravaioli, M. Del Gaudio, F. Tuci, M. Zanello, A. Cucchetti, A. D. Pinna

Research output: Contribution to journalArticle

Abstract

Aim. The aim of this study was to evaluate the role of surgery in the treatment of non-colorectal, non-neuroendocrine (NCRNNE) liver metastases. Methods. One hundred and thirty-four patients undergoing curative liver resection for NCRNNE liver metastases were retrospectively analyzed. Perioperative results (blood transfusion, hospital stay, morbidity and mortality), 3 and 5year overall and disease-free survival were evaluated. The following prognostic factors were analyzed: age (cut-off 50 year old), single vs. multiple nodules, diameter (cut-off 5 cm), disease-free interval less vs. more than one year, type of primary tumor, blood transfusion, major hepatectomy vs. minor hepatectomy. Survival of patients undergoing liver resection for metastatic colorectal cancer was also analyzed to compare the results with the study population. Results. Mortality and morbidity rate were 3% and 23.1%, respectively. The 3 and 5-year survival were 56.5% and 40%, respectively. The 3 and 5-year disease-free survival were 44% and 30%, respectively. Diameter, disease-free interval and metastases from gastrointestinal cancers were independently related to the survival at the multivariate analysis. Thirty-nine patients (27%) survived over five years. Patients with liver metastases from gastrointestinal primary tumors were those with a worse survival (25% and 19% at 3 and 5 years, respectively). Conclusion. Surgery is an effective treatment for patients with NCRNNE liver metastases, providing satisfactory long-term outcomes with acceptable morbidity and mortality, in particular when excluding patients with gastrointestinal metastases.

Original languageEnglish
Pages (from-to)551-558
Number of pages8
JournalMinerva Chirurgica
Volume64
Issue number6
Publication statusPublished - Dec 2009

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Neoplasm Metastasis
Liver
Survival
Hepatectomy
Therapeutics
Morbidity
Blood Transfusion
Disease-Free Survival
Gastrointestinal Neoplasms
Mortality
Hospital Mortality
Colorectal Neoplasms
Length of Stay
Neoplasms
Multivariate Analysis
Population

Keywords

  • Liver neoplasms, surgery
  • Neoplasm metastasis
  • Survivors

ASJC Scopus subject areas

  • Surgery

Cite this

Ercolani, G., Vetrone, G., Grazi, G. L., Cescon, M., Gioia, P. D. I., Ravaioli, M., ... Pinna, A. D. (2009). The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients. Minerva Chirurgica, 64(6), 551-558.

The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients. / Ercolani, G.; Vetrone, G.; Grazi, G. L.; Cescon, M.; Gioia, P. D I; Ravaioli, M.; Del Gaudio, M.; Tuci, F.; Zanello, M.; Cucchetti, A.; Pinna, A. D.

In: Minerva Chirurgica, Vol. 64, No. 6, 12.2009, p. 551-558.

Research output: Contribution to journalArticle

Ercolani, G, Vetrone, G, Grazi, GL, Cescon, M, Gioia, PDI, Ravaioli, M, Del Gaudio, M, Tuci, F, Zanello, M, Cucchetti, A & Pinna, AD 2009, 'The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients', Minerva Chirurgica, vol. 64, no. 6, pp. 551-558.
Ercolani, G. ; Vetrone, G. ; Grazi, G. L. ; Cescon, M. ; Gioia, P. D I ; Ravaioli, M. ; Del Gaudio, M. ; Tuci, F. ; Zanello, M. ; Cucchetti, A. ; Pinna, A. D. / The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients. In: Minerva Chirurgica. 2009 ; Vol. 64, No. 6. pp. 551-558.
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abstract = "Aim. The aim of this study was to evaluate the role of surgery in the treatment of non-colorectal, non-neuroendocrine (NCRNNE) liver metastases. Methods. One hundred and thirty-four patients undergoing curative liver resection for NCRNNE liver metastases were retrospectively analyzed. Perioperative results (blood transfusion, hospital stay, morbidity and mortality), 3 and 5year overall and disease-free survival were evaluated. The following prognostic factors were analyzed: age (cut-off 50 year old), single vs. multiple nodules, diameter (cut-off 5 cm), disease-free interval less vs. more than one year, type of primary tumor, blood transfusion, major hepatectomy vs. minor hepatectomy. Survival of patients undergoing liver resection for metastatic colorectal cancer was also analyzed to compare the results with the study population. Results. Mortality and morbidity rate were 3{\%} and 23.1{\%}, respectively. The 3 and 5-year survival were 56.5{\%} and 40{\%}, respectively. The 3 and 5-year disease-free survival were 44{\%} and 30{\%}, respectively. Diameter, disease-free interval and metastases from gastrointestinal cancers were independently related to the survival at the multivariate analysis. Thirty-nine patients (27{\%}) survived over five years. Patients with liver metastases from gastrointestinal primary tumors were those with a worse survival (25{\%} and 19{\%} at 3 and 5 years, respectively). Conclusion. Surgery is an effective treatment for patients with NCRNNE liver metastases, providing satisfactory long-term outcomes with acceptable morbidity and mortality, in particular when excluding patients with gastrointestinal metastases.",
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T1 - The role of liver surgery in the treatment of non-colorectal non-neuroendocrine metastases (NCRNNE) Analysis of 134 resected patients

AU - Ercolani, G.

AU - Vetrone, G.

AU - Grazi, G. L.

AU - Cescon, M.

AU - Gioia, P. D I

AU - Ravaioli, M.

AU - Del Gaudio, M.

AU - Tuci, F.

AU - Zanello, M.

AU - Cucchetti, A.

AU - Pinna, A. D.

PY - 2009/12

Y1 - 2009/12

N2 - Aim. The aim of this study was to evaluate the role of surgery in the treatment of non-colorectal, non-neuroendocrine (NCRNNE) liver metastases. Methods. One hundred and thirty-four patients undergoing curative liver resection for NCRNNE liver metastases were retrospectively analyzed. Perioperative results (blood transfusion, hospital stay, morbidity and mortality), 3 and 5year overall and disease-free survival were evaluated. The following prognostic factors were analyzed: age (cut-off 50 year old), single vs. multiple nodules, diameter (cut-off 5 cm), disease-free interval less vs. more than one year, type of primary tumor, blood transfusion, major hepatectomy vs. minor hepatectomy. Survival of patients undergoing liver resection for metastatic colorectal cancer was also analyzed to compare the results with the study population. Results. Mortality and morbidity rate were 3% and 23.1%, respectively. The 3 and 5-year survival were 56.5% and 40%, respectively. The 3 and 5-year disease-free survival were 44% and 30%, respectively. Diameter, disease-free interval and metastases from gastrointestinal cancers were independently related to the survival at the multivariate analysis. Thirty-nine patients (27%) survived over five years. Patients with liver metastases from gastrointestinal primary tumors were those with a worse survival (25% and 19% at 3 and 5 years, respectively). Conclusion. Surgery is an effective treatment for patients with NCRNNE liver metastases, providing satisfactory long-term outcomes with acceptable morbidity and mortality, in particular when excluding patients with gastrointestinal metastases.

AB - Aim. The aim of this study was to evaluate the role of surgery in the treatment of non-colorectal, non-neuroendocrine (NCRNNE) liver metastases. Methods. One hundred and thirty-four patients undergoing curative liver resection for NCRNNE liver metastases were retrospectively analyzed. Perioperative results (blood transfusion, hospital stay, morbidity and mortality), 3 and 5year overall and disease-free survival were evaluated. The following prognostic factors were analyzed: age (cut-off 50 year old), single vs. multiple nodules, diameter (cut-off 5 cm), disease-free interval less vs. more than one year, type of primary tumor, blood transfusion, major hepatectomy vs. minor hepatectomy. Survival of patients undergoing liver resection for metastatic colorectal cancer was also analyzed to compare the results with the study population. Results. Mortality and morbidity rate were 3% and 23.1%, respectively. The 3 and 5-year survival were 56.5% and 40%, respectively. The 3 and 5-year disease-free survival were 44% and 30%, respectively. Diameter, disease-free interval and metastases from gastrointestinal cancers were independently related to the survival at the multivariate analysis. Thirty-nine patients (27%) survived over five years. Patients with liver metastases from gastrointestinal primary tumors were those with a worse survival (25% and 19% at 3 and 5 years, respectively). Conclusion. Surgery is an effective treatment for patients with NCRNNE liver metastases, providing satisfactory long-term outcomes with acceptable morbidity and mortality, in particular when excluding patients with gastrointestinal metastases.

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KW - Neoplasm metastasis

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