The Role of Lymphadenectomy for Liver Tumors: Further Considerations on the Appropriateness of Treatment Strategy

Giorgio Ercolani, Gian Luca Grazi, Matteo Ravaioli, Walter Franco Grigioni, Matteo Cescon, Andrea Gardini, Massimo Del Gaudio, Antonino Cavallari

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the role of regional lymphadenectomy in patients with liver tumors. Background: Lymph node status is 1 of the most important prognostic factors in oncologic surgery; however, the role of lymph node dissection remains unclear for hepatic tumors. Methods: A total of 120 consecutive patients undergoing liver resections for primary and secondary hepatic tumors were prospectively enrolled in the study. "Regional" lymphadenectomy was carried out routinely after specimen removal. Incidence, site, and influence on survival of node metastases were analyzed. Results: Only 1 postoperative complication (intra-abdominal bleeding) was related to lymph node excision. Median number of dissected nodes was 6.8 ± 3.6. Periportal, pericholedochal, and common hepatic artery stations were always removed. Lymph node metastases were found in 17 (16.5%) patients. The percentage rises to 20.3% when considering only noncirrhotic patients. The incidence of lymph node metastases was 7.5% for hepatocellular carcinoma, 14% for colorectal metastases, 40% for noncolorectal metastases, and 40% for intrahepatic cholangiocarcinoma (P <0.002). Median survival time was 486 ± 93.2 days among all patients with node metastases and 725 ± 29. 7 among patients without node metastases. The 2-year survival was 37.1% and 86.7%, in the 2 groups (P <0.05). The 2-year recurrence rate was 77.6% and 45.3%, respectively (P <0.05). Conclusions: Regional lymphadenectomy is a safe procedure after liver resection, and it should be routinely applied in patients with primary and secondary hepatic tumors, particularly in those without chronic disease. A careful evaluation of node status is nevertheless advisable also in patients with hepatocellular carcinoma on cirrhosis.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalAnnals of Surgery
Volume239
Issue number2
DOIs
Publication statusPublished - Feb 2004

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Lymph Node Excision
Neoplasm Metastasis
Liver
Neoplasms
Lymph Nodes
Therapeutics
Survival
Hepatocellular Carcinoma
Cholangiocarcinoma
Hepatic Artery
Incidence
Fibrosis
Chronic Disease
Hemorrhage
Recurrence

ASJC Scopus subject areas

  • Surgery

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The Role of Lymphadenectomy for Liver Tumors : Further Considerations on the Appropriateness of Treatment Strategy. / Ercolani, Giorgio; Grazi, Gian Luca; Ravaioli, Matteo; Grigioni, Walter Franco; Cescon, Matteo; Gardini, Andrea; Del Gaudio, Massimo; Cavallari, Antonino.

In: Annals of Surgery, Vol. 239, No. 2, 02.2004, p. 202-209.

Research output: Contribution to journalArticle

Ercolani, G, Grazi, GL, Ravaioli, M, Grigioni, WF, Cescon, M, Gardini, A, Del Gaudio, M & Cavallari, A 2004, 'The Role of Lymphadenectomy for Liver Tumors: Further Considerations on the Appropriateness of Treatment Strategy', Annals of Surgery, vol. 239, no. 2, pp. 202-209. https://doi.org/10.1097/01.sla.0000109154.00020.e0
Ercolani, Giorgio ; Grazi, Gian Luca ; Ravaioli, Matteo ; Grigioni, Walter Franco ; Cescon, Matteo ; Gardini, Andrea ; Del Gaudio, Massimo ; Cavallari, Antonino. / The Role of Lymphadenectomy for Liver Tumors : Further Considerations on the Appropriateness of Treatment Strategy. In: Annals of Surgery. 2004 ; Vol. 239, No. 2. pp. 202-209.
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T2 - Further Considerations on the Appropriateness of Treatment Strategy

AU - Ercolani, Giorgio

AU - Grazi, Gian Luca

AU - Ravaioli, Matteo

AU - Grigioni, Walter Franco

AU - Cescon, Matteo

AU - Gardini, Andrea

AU - Del Gaudio, Massimo

AU - Cavallari, Antonino

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N2 - Objective: To evaluate the role of regional lymphadenectomy in patients with liver tumors. Background: Lymph node status is 1 of the most important prognostic factors in oncologic surgery; however, the role of lymph node dissection remains unclear for hepatic tumors. Methods: A total of 120 consecutive patients undergoing liver resections for primary and secondary hepatic tumors were prospectively enrolled in the study. "Regional" lymphadenectomy was carried out routinely after specimen removal. Incidence, site, and influence on survival of node metastases were analyzed. Results: Only 1 postoperative complication (intra-abdominal bleeding) was related to lymph node excision. Median number of dissected nodes was 6.8 ± 3.6. Periportal, pericholedochal, and common hepatic artery stations were always removed. Lymph node metastases were found in 17 (16.5%) patients. The percentage rises to 20.3% when considering only noncirrhotic patients. The incidence of lymph node metastases was 7.5% for hepatocellular carcinoma, 14% for colorectal metastases, 40% for noncolorectal metastases, and 40% for intrahepatic cholangiocarcinoma (P <0.002). Median survival time was 486 ± 93.2 days among all patients with node metastases and 725 ± 29. 7 among patients without node metastases. The 2-year survival was 37.1% and 86.7%, in the 2 groups (P <0.05). The 2-year recurrence rate was 77.6% and 45.3%, respectively (P <0.05). Conclusions: Regional lymphadenectomy is a safe procedure after liver resection, and it should be routinely applied in patients with primary and secondary hepatic tumors, particularly in those without chronic disease. A careful evaluation of node status is nevertheless advisable also in patients with hepatocellular carcinoma on cirrhosis.

AB - Objective: To evaluate the role of regional lymphadenectomy in patients with liver tumors. Background: Lymph node status is 1 of the most important prognostic factors in oncologic surgery; however, the role of lymph node dissection remains unclear for hepatic tumors. Methods: A total of 120 consecutive patients undergoing liver resections for primary and secondary hepatic tumors were prospectively enrolled in the study. "Regional" lymphadenectomy was carried out routinely after specimen removal. Incidence, site, and influence on survival of node metastases were analyzed. Results: Only 1 postoperative complication (intra-abdominal bleeding) was related to lymph node excision. Median number of dissected nodes was 6.8 ± 3.6. Periportal, pericholedochal, and common hepatic artery stations were always removed. Lymph node metastases were found in 17 (16.5%) patients. The percentage rises to 20.3% when considering only noncirrhotic patients. The incidence of lymph node metastases was 7.5% for hepatocellular carcinoma, 14% for colorectal metastases, 40% for noncolorectal metastases, and 40% for intrahepatic cholangiocarcinoma (P <0.002). Median survival time was 486 ± 93.2 days among all patients with node metastases and 725 ± 29. 7 among patients without node metastases. The 2-year survival was 37.1% and 86.7%, in the 2 groups (P <0.05). The 2-year recurrence rate was 77.6% and 45.3%, respectively (P <0.05). Conclusions: Regional lymphadenectomy is a safe procedure after liver resection, and it should be routinely applied in patients with primary and secondary hepatic tumors, particularly in those without chronic disease. A careful evaluation of node status is nevertheless advisable also in patients with hepatocellular carcinoma on cirrhosis.

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