The role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis

Carlo Lorenzo Cazzullo; Domenico Caputo; Angelo Ghezzi; Mauro Zaffaroni

doi:10.1159/000116121

The role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis

Carlo Lorenzo Cazzullo, Domenico Caputo, Angelo Ghezzi, Mauro Zaffaroni

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Thirty patients with definite multiple sclerosis (MS) were examined monthly for one year. Each time, neurological examination, clinical history and monoclonal-antibody-defined Τ cell subsets were evaluated. Particularly, the helper/suppressor ratio (T4/T8) and the T4/T8 test-to-test variability (ΔΤ4/Τ8) were considered in relation to the occurrence of clinical exacerbations. Statistically significant correlations were found between clinical course and laboratory parameters, suggesting a possible role of Τ cell subset analysis in defining the clinical evolution of MS.

Original language	English
Pages (from-to)	5-12
Number of pages	8
Journal	European Neurology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1159/000116121
Publication status	Published - 1987

Keywords

Clinical follow-up
Monoclonal antibodies
Multiple sclerosis
Τ cell subsets

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1159/000116121

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AB - Thirty patients with definite multiple sclerosis (MS) were examined monthly for one year. Each time, neurological examination, clinical history and monoclonal-antibody-defined Τ cell subsets were evaluated. Particularly, the helper/suppressor ratio (T4/T8) and the T4/T8 test-to-test variability (ΔΤ4/Τ8) were considered in relation to the occurrence of clinical exacerbations. Statistically significant correlations were found between clinical course and laboratory parameters, suggesting a possible role of Τ cell subset analysis in defining the clinical evolution of MS.

KW - Clinical follow-up

KW - Monoclonal antibodies

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The role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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