The role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis

Carlo Lorenzo Cazzullo, Domenico Caputo, Angelo Ghezzi, Mauro Zaffaroni

Research output: Contribution to journalArticle


Thirty patients with definite multiple sclerosis (MS) were examined monthly for one year. Each time, neurological examination, clinical history and monoclonal-antibody-defined Τ cell subsets were evaluated. Particularly, the helper/suppressor ratio (T4/T8) and the T4/T8 test-to-test variability (ΔΤ4/Τ8) were considered in relation to the occurrence of clinical exacerbations. Statistically significant correlations were found between clinical course and laboratory parameters, suggesting a possible role of Τ cell subset analysis in defining the clinical evolution of MS.

Original languageEnglish
Pages (from-to)5-12
Number of pages8
JournalEuropean Neurology
Issue number1
Publication statusPublished - 1987



  • Clinical follow-up
  • Monoclonal antibodies
  • Multiple sclerosis
  • Τ cell subsets

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this