The role of lymphoscintigraphy in the diagnosis of lymphedema in Turner syndrome

Carlo Bellini, E. Di Battista, F. Boccardo, C. Campisi, G. Villa, G. Taddei, C. Traggiai, A. Amisamo, P. Polo Perucchin, C. S. Benfenati, E. Bonioli, R. Lorini

Research output: Contribution to journalArticlepeer-review


Lymphedema can be present in patients affected by Turner syndrome (TS) with the dorsum of the hands and feet most commonly affected. This lymphedema results from underdevelopment of the lymphatic system before birth, and it usually decreases during childhood. The aim of our study was to evaluate the role of lymphoscintigraphy as a diagnostic tool in patients with TS to assess possible impairments in the lymphatic system. Eighteen patients with TS were karyotyped to confirm diagnosis and were evaluated by lymphoscintigraphy. Lymphatic dysfunction was demonstrated in 15118 patients. Lymphoscintigraphic studies showed: 1) lymphatic channels, 2) collateral lymphatic channels, 3) interrupted lymphatic structures, and 4) lymph nodes of the deep lymphatic system. Our data demonstrate that lymphoscintigraphy should be mandatory not only in patients affected by Turner syndrome with signs of lymphatic dysplasia but also in those with minimal or absent signs of lymphatic impairment in order to obtain a very early diagnosis and to provide substantial information for possible medical or surgical treatment.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
Issue number3
Publication statusPublished - Sep 2009


  • Congenital lymphatic dysplasia
  • Lymphedema
  • Lymphoscintigraphy
  • Turner syndrome

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy


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