The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective?

Maria Cristina Petralia; Giuseppe Battaglia; Valeria Bruno; Manuela Pennisi; Katia Mangano; Salvo Danilo Lombardo; Paolo Fagone; Eugenio Cavalli; Andrea Saraceno; Ferdinando Nicoletti; Maria Sofia Basile

doi:10.3390/molecules25020291

The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective?

Maria Cristina Petralia, Giuseppe Battaglia, Valeria Bruno, Manuela Pennisi, Katia Mangano, Salvo Danilo Lombardo, Paolo Fagone, Eugenio Cavalli, Andrea Saraceno, Ferdinando Nicoletti, Maria Sofia Basile

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Research output: Contribution to journal › Review article › peer-review

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Abstract

Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer's disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.

Original language	English
Journal	Molecules (Basel, Switzerland)
Volume	25
Issue number	2
DOIs	https://doi.org/10.3390/molecules25020291
Publication status	Published - Jan 10 2020

Keywords

Alzheimer Disease/diagnosis
Animals
Disease Models, Animal
Humans
Intramolecular Oxidoreductases/genetics
Macrophage Migration-Inhibitory Factors/genetics
Macrophages
Receptors, Immunologic/genetics
Rodentia
Up-Regulation/immunology

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10.3390/molecules25020291

The Role of Macrophage Migration

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Petralia, M. C., Battaglia, G., Bruno, V., Pennisi, M., Mangano, K., Lombardo, S. D., Fagone, P., Cavalli, E., Saraceno, A., Nicoletti, F., & Basile, M. S. (2020). The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective? Molecules (Basel, Switzerland), 25(2). https://doi.org/10.3390/molecules25020291

The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease : Conventionally Pathogenetic or Unconventionally Protective? / Petralia, Maria Cristina; Battaglia, Giuseppe; Bruno, Valeria; Pennisi, Manuela; Mangano, Katia; Lombardo, Salvo Danilo; Fagone, Paolo; Cavalli, Eugenio; Saraceno, Andrea; Nicoletti, Ferdinando; Basile, Maria Sofia.

In: Molecules (Basel, Switzerland), Vol. 25, No. 2, 10.01.2020.

Research output: Contribution to journal › Review article › peer-review

Petralia, MC, Battaglia, G, Bruno, V, Pennisi, M, Mangano, K, Lombardo, SD, Fagone, P, Cavalli, E, Saraceno, A, Nicoletti, F & Basile, MS 2020, 'The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective?', Molecules (Basel, Switzerland), vol. 25, no. 2. https://doi.org/10.3390/molecules25020291

Petralia, Maria Cristina ; Battaglia, Giuseppe ; Bruno, Valeria ; Pennisi, Manuela ; Mangano, Katia ; Lombardo, Salvo Danilo ; Fagone, Paolo ; Cavalli, Eugenio ; Saraceno, Andrea ; Nicoletti, Ferdinando ; Basile, Maria Sofia. / The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease : Conventionally Pathogenetic or Unconventionally Protective?. In: Molecules (Basel, Switzerland). 2020 ; Vol. 25, No. 2.

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abstract = "Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer's disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.",

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AU - Pennisi, Manuela

AU - Mangano, Katia

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AU - Fagone, Paolo

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AB - Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer's disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.

KW - Alzheimer Disease/diagnosis

KW - Animals

KW - Disease Models, Animal

KW - Humans

KW - Intramolecular Oxidoreductases/genetics

KW - Macrophage Migration-Inhibitory Factors/genetics

KW - Macrophages

KW - Receptors, Immunologic/genetics

KW - Rodentia

KW - Up-Regulation/immunology

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